Reactome | Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation

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Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
dbId	975097
displayName	Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
edited	[InstanceEdit:1014262] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation - Homo sapiens
followingEvent	[Reaction:R-HSA-975103] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation - Homo sapiens
input	3 × [Polymer:R-HSA-450152] K63polyUb [cytosol] [Complex:R-HSA-975164] p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] 3 × [Complex:R-HSA-446878] TAK1 complex [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains [LiteratureReference:208226] TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains [LiteratureReference:208287] TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
orthologousEvent	[Reaction:R-GGA-573296] Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation - Gallus gallus [Reaction:R-GGA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Gallus gallus [Reaction:R-SSC-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Sus scrofa [Reaction:R-BTA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Bos taurus [Reaction:R-CFA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Canis familiaris [Reaction:R-RNO-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Rattus norvegicus [Reaction:R-MMU-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Mus musculus
output	[Complex:R-HSA-975099] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane]
precedingEvent	[Polymerisation:R-HSA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Homo sapiens [BlackBoxEvent:R-HSA-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-975097
summation	[Summation:447018] TAK1-binding protein 2 (TAB2) and/or TAB3, as part of a comp...
updateTrackers	[UpdateTracker:9776371] Update Tracker - [Reaction:975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - v76:[modifyText] [UpdateTracker:9788163] Update Tracker - [Reaction:975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - v43:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776371] Update Tracker - [Reaction:975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - v76:[modifyText] [UpdateTracker:9788163] Update Tracker - [Reaction:975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - v43:[modifyText]
(hasEvent)	[Pathway:R-HSA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
(precedingEvent)	[Reaction:R-HSA-975103] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation

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