Reactome | Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation

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Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation Show undefined attributes

catalystActivity	[CatalystActivity:10760874] ubiquitin-protein transferase activity of K63-linked polyUb TRAF6 complexes [endosome membrane]
category	binding
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10760876
displayName	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
eventOf	[Pathway:R-GGA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Gallus gallus
inferredFrom	[Polymerisation:R-HSA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Homo sapiens
input	[DefinedSet:R-GGA-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
output	[Polymer:R-GGA-450152] K63polyUb [cytosol]
precedingEvent	[BlackBoxEvent:R-GGA-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Gallus gallus [BlackBoxEvent:R-GGA-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - Gallus gallus
releaseDate	2026-03-25
schemaClass	Polymerisation
species	[Species:49591] Gallus gallus
stId	R-GGA-450358
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation [Pathway:R-GGA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex
(precedingEvent)	[Reaction:R-GGA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
(inferredTo)	[Polymerisation:R-HSA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation

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