Reactome | Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane

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Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
catalystActivity	[CatalystActivity:1014251] ubiquitin-protein transferase activity of p-IRAK2:oligo-TRAF6 [endosome membrane]
category	omitted
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
dbId	975147
displayName	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
edited	[InstanceEdit:1014262] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation - Homo sapiens
followingEvent	[Polymerisation:R-HSA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Homo sapiens [Reaction:R-HSA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Homo sapiens
input	[Complex:R-HSA-975137] p-IRAK2:oligo-TRAF6 [endosome membrane] 9 × [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202511] Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
orthologousEvent	[BlackBoxEvent:R-GGA-571318] Autoubiquitination of oligoTRAF6 bound to p-IRAK2 - Gallus gallus [BlackBoxEvent:R-DDI-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Dictyostelium discoideum [BlackBoxEvent:R-DME-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Drosophila melanogaster [BlackBoxEvent:R-GGA-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Gallus gallus [BlackBoxEvent:R-DRE-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Danio rerio [BlackBoxEvent:R-SSC-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Sus scrofa [BlackBoxEvent:R-BTA-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Bos taurus [BlackBoxEvent:R-CFA-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Canis familiaris [BlackBoxEvent:R-RNO-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Rattus norvegicus [BlackBoxEvent:R-MMU-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Mus musculus
output	[Complex:R-HSA-975164] p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane]
precedingEvent	[Reaction:R-HSA-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Homo sapiens
releaseDate	2010-12-14
requiredInputComponent	[Complex:R-HSA-202463] UBE2N:UBE2V1 [cytosol] - Homo sapiens
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-975147
summation	[Summation:202446] TRAF6 possesses ubiquitin ligase activity and undergoes K-63...
updateTrackers	[UpdateTracker:9789990] Update Tracker - [BlackBoxEvent:975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - v36:[modifyText] [UpdateTracker:9788145] Update Tracker - [BlackBoxEvent:975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - v43:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789990] Update Tracker - [BlackBoxEvent:975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - v36:[modifyText] [UpdateTracker:9788145] Update Tracker - [BlackBoxEvent:975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - v43:[modifyText]
(hasEvent)	[Pathway:R-HSA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
(precedingEvent)	[Reaction:R-HSA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation [Polymerisation:R-HSA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation

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