Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation

Stable Identifier
R-HSA-450358
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Polyubiquitinated TRAF6 (as E3 ubiquitin ligase) generates free K63 -linked polyubiquitin chains that non-covalently associate with ubiquitin receptors of TAB2/TAB3 regulatory proteins of the TAK1 complex, leading to the activation of the TAK1 kinase.

Literature References
PubMed ID Title Journal Year
19675569 Direct activation of protein kinases by unanchored polyubiquitin chains

Xia, ZP, Sun, L, Chen, X, Pineda, G, Jiang, X, Adhikari, A, Zeng, W, Chen, ZJ

Nature 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of K63-linked polyUb TRAF6 complexes [endosome membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created