Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation

Stable Identifier
R-HSA-450358
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endosome membrane
ReviewStatus
5/5
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Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
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Polyubiquitinated TRAF6 (as E3 ubiquitin ligase) generates free K63 -linked polyubiquitin chains that non-covalently associate with ubiquitin receptors of TAB2/TAB3 regulatory proteins of the TAK1 complex, leading to the activation of the TAK1 kinase.
Literature References
PubMed ID Title Journal Year
19675569 Direct activation of protein kinases by unanchored polyubiquitin chains

Adhikari, A, Zeng, W, Chen, ZJ, Pineda, G, Sun, L, Chen, X, Jiang, X, Xia, ZP

Nature 2009
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Catalyst Activity

ubiquitin-protein transferase activity of K63-linked polyUb TRAF6 complexes [endosome membrane]

Physical Entity
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
Activated TRAF6 synthesizes free K63 linked pUb chains (Gallus gallus)
Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1 (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Bos taurus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Canis familiaris)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Drosophila melanogaster)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Mus musculus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Rattus norvegicus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Sus scrofa)
Authored
Shamovsky, V  (2009-12-16)
Reviewed
Gillespie, ME  (2010-03-02)
Created
Shamovsky, V  (2009-12-16)
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