Reactome | Activation of the AP-1 family of transcription factors

Schema > Pathway > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10911238
displayName	Activation of the AP-1 family of transcription factors
eventOf	[Pathway:R-DME-450282] MAPK targets/ Nuclear events mediated by MAP kinases - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Drosophila melanogaster [Reaction:R-DME-450325] c-FOS activation by phospho ERK1/2 - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-450341] Activation of the AP-1 family of transcription factors - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Activation of the AP-1 family of transcription factors
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-450341
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-450282] MAPK targets/ Nuclear events mediated by MAP kinases
(inferredTo)	[Pathway:R-HSA-450341] Activation of the AP-1 family of transcription factors

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