Reactome | NEDD8 [cytosol]

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NEDD8 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-5691141] SKP1:FBXL5:CUL1:NEDD8 [cytosol] - Homo sapiens [Complex:R-HSA-6782643] UCHL3,SENP8:NEDD8 [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 - Homo sapiens [Reaction:R-HSA-8951656] NEDD8-UBA3:NAE1 binds a second NEDD8 - Homo sapiens [Reaction:R-HSA-5691176] NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) - Homo sapiens
created	[InstanceEdit:416970] Matthews, L, 2009-04-07 00:38:16
dbId	416969
displayName	NEDD8 [cytosol]
endCoordinate	76
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-416969] Nedd8 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-416969] Nedd8 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-416969] NEDD8 [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-416969] NEDD8 [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-416969] NEDD8 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-416969] nedd8 [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-DRE-416969-2] nedd8l [cytosol] - Danio rerio [DefinedSet:R-DRE-416969-3] Homologues of NEDD8 [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-XTR-416969] nedd8 [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-416969] NEDD8 [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-416969] Nedd8 [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-416969] ned-8 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-416969] nedd8 [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-SPO-416969] ubl1 [cytosol] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-416969] RUB1 [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-PFA-416969] NEDD8 [cytosol] - Plasmodium falciparum
maxDepth	1
memberOf	[DefinedSet:R-HSA-8956136] NEDD8,UBD [cytosol] - Homo sapiens
modified	[InstanceEdit:8871616] Weiser, JD
name	NEDD8 NEDD8_HUMAN
producedByEvent	[Reaction:R-HSA-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Homo sapiens [Reaction:R-HSA-8951644] Release of mature NEDD8 - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q15843] UniProt:Q15843 NEDD8
referenceType	ReferenceGeneProduct
repeatedUnitOf	[Polymer:R-HSA-9764248] monoNEDD8 [cytosol] - Homo sapiens
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-416969
startCoordinate	1

Referrals

(output)	[Reaction:R-HSA-8951644] Release of mature NEDD8 [Reaction:R-HSA-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
(hasComponent)	[Complex:R-HSA-6782643] UCHL3,SENP8:NEDD8 [cytosol] [Complex:R-HSA-8951658] NEDD8-UBA3:NAE1:NEDD8 [cytosol] [Complex:R-HSA-5691141] SKP1:FBXL5:CUL1:NEDD8 [cytosol]
(input)	[Reaction:R-HSA-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 [Reaction:R-HSA-8951656] NEDD8-UBA3:NAE1 binds a second NEDD8 [Reaction:R-HSA-5691176] NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)
(hasMember)	[DefinedSet:R-HSA-8956136] NEDD8,UBD [cytosol]
(repeatedUnit)	[Polymer:R-HSA-9764248] monoNEDD8 [cytosol]

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