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Schema
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Reaction
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Entries
NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)
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authored
[InstanceEdit:5691161] Jassal, Bijay, 2015-05-05
category
binding
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:5691161] Jassal, Bijay, 2015-05-05
dbId
5691176
displayName
NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)
edited
[InstanceEdit:5691161] Jassal, Bijay, 2015-05-05
eventOf
[Pathway:R-HSA-917937] Iron uptake and transport - Homo sapiens
followingEvent
[Reaction:R-HSA-5691108] SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-416969] NEDD8 [cytosol]
[Complex:R-HSA-5691178] SKP1:CUL1:FBXL5 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5691194] Covalent modification of all members of human cullin family proteins by NEDD8
maxDepth
1
modified
[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name
NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)
orthologousEvent
[Reaction:R-SCE-5691176] NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) - Saccharomyces cerevisiae
[Reaction:R-DDI-5691176] NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) - Dictyostelium discoideum
[Reaction:R-DRE-5691176] NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) - Danio rerio
[Reaction:R-BTA-5691176] NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) - Bos taurus
[Reaction:R-CFA-5691176] NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) - Canis familiaris
[Reaction:R-RNO-5691176] NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) - Rattus norvegicus
[Reaction:R-MMU-5691176] NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) - Mus musculus
output
[Complex:R-HSA-5691141] SKP1:FBXL5:CUL1:NEDD8 [cytosol]
precedingEvent
[Reaction:R-HSA-5691167] CUL1, SKP1, FBXL5 bind - Homo sapiens
releaseDate
2017-03-27
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8954302] D'Eustachio, Peter, 2017-01-06
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5691176
summation
[Summation:5691144] Cellular iron homeostasis is maintained by the coordinate po...
Referrals
(hasEvent)
[Pathway:R-HSA-917937] Iron uptake and transport
(precedingEvent)
[Reaction:R-HSA-5691108] SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2
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