Reactome | NEDD8 covalently binds catalytic cysteine of UBA3:NAE1

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NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 Show undefined attributes

authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
catalystActivity	[CatalystActivity:8953292] NEDD8 transferase activity of UBA3:NAE1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8951645] Rothfels, Karen, 2016-12-08
dbId	8951648
displayName	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
eventOf	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
followingEvent	[Reaction:R-HSA-8951656] NEDD8-UBA3:NAE1 binds a second NEDD8 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-416969] NEDD8 [cytosol] [Complex:R-HSA-8951642] UBA3:NAE1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8951606] The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1 [LiteratureReference:8951615] A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8 [LiteratureReference:8951603] Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1 [LiteratureReference:8951620] Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1
negativePrecedingEvent	[NegativePrecedingEvent:9767189] Futile Cycle: COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
orthologousEvent	[Reaction:R-PFA-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 - Plasmodium falciparum [Reaction:R-SCE-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 - Saccharomyces cerevisiae [Reaction:R-SPO-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 - Schizosaccharomyces pombe [Reaction:R-DDI-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 - Dictyostelium discoideum [Reaction:R-CEL-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 - Caenorhabditis elegans [Reaction:R-DME-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 - Drosophila melanogaster [Reaction:R-GGA-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 - Gallus gallus [Reaction:R-DRE-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 - Danio rerio [Reaction:R-BTA-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 - Bos taurus [Reaction:R-CFA-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 - Canis familiaris [Reaction:R-RNO-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 - Rattus norvegicus [Reaction:R-MMU-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 - Mus musculus
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [Complex:R-HSA-8951646] NEDD8-UBA3:NAE1 [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-8951644] Release of mature NEDD8 - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8951648
summation	[Summation:8951649] NEDD8 is attached via a thioester bond to the catalytic cyst...

Referrals

(hasEvent)	[Pathway:R-HSA-8951664] Neddylation
(precedingEvent)	[Reaction:R-HSA-8951656] NEDD8-UBA3:NAE1 binds a second NEDD8

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