Reactome | NEDD8 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-BTA-5691141] SKP1:FBXL5:CUL1:NEDD8 [cytosol] - Bos taurus [Complex:R-BTA-6782643] UCHL3,SENP8:NEDD8 [cytosol] - Bos taurus
consumedByEvent	[Reaction:R-BTA-8951656] NEDD8-UBA3:NAE1 binds a second NEDD8 - Bos taurus [Reaction:R-BTA-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 - Bos taurus [Reaction:R-BTA-5691176] NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) - Bos taurus
created	[InstanceEdit:10203599] Wright, Adam, 2024-03-07
dbId	10279842
displayName	NEDD8 [cytosol]
endCoordinate	76
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-416969] NEDD8 [cytosol] - Homo sapiens
memberOf	[DefinedSet:R-BTA-8956136] NEDD8,UBD [cytosol] - Bos taurus
name	NEDD8 NEDD8 P61282
producedByEvent	[Reaction:R-BTA-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Bos taurus [Reaction:R-BTA-8951644] Release of mature NEDD8 - Bos taurus
referenceEntity	[ReferenceGeneProduct:10267632] UniProt:P61282
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48898] Bos taurus
stId	R-BTA-416969
startCoordinate	1

(output)	[Reaction:R-BTA-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes [Reaction:R-BTA-8951644] Release of mature NEDD8
(input)	[Reaction:R-BTA-8951656] NEDD8-UBA3:NAE1 binds a second NEDD8 [Reaction:R-BTA-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 [Reaction:R-BTA-5691176] NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)
(hasComponent)	[Complex:R-BTA-6782643] UCHL3,SENP8:NEDD8 [cytosol] [Complex:R-BTA-8951658] NEDD8-UBA3:NAE1:NEDD8 [cytosol] [Complex:R-BTA-5691141] SKP1:FBXL5:CUL1:NEDD8 [cytosol]
(hasMember)	[DefinedSet:R-BTA-8956136] NEDD8,UBD [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-416969] NEDD8 [cytosol]