Reactome | NEDD8-UBA3:NAE1 binds a second NEDD8

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NEDD8-UBA3:NAE1 binds a second NEDD8 Show undefined attributes

authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8951657] Rothfels, Karen, 2016-12-08
dbId	8951656
displayName	NEDD8-UBA3:NAE1 binds a second NEDD8
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
eventOf	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
followingEvent	[Reaction:R-HSA-8951751] Doubly neddylated UBA3:NAE1 binds AcM-UBE2M - Homo sapiens [Reaction:R-HSA-8951766] Doubly neddylated UBA3:NAE1 binds AcM-UBE2F - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-416969] NEDD8 [cytosol] [Complex:R-HSA-8951646] NEDD8-UBA3:NAE1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8951620] Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity [LiteratureReference:8951603] Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1 [LiteratureReference:5690803] Protein neddylation: beyond cullin-RING ligases
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NEDD8-UBA3:NAE1 binds a second NEDD8
negativePrecedingEvent	[NegativePrecedingEvent:9767192] Abundant Molecules: COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes [NegativePrecedingEvent:9767193] Incorrect Order: Release of mature NEDD8 [NegativePrecedingEvent:9767194] Futile Cycle: Transfer of NEDD8 to AcM-UBE2F [NegativePrecedingEvent:9767191] Futile Cycle: Transfer of NEDD8 to AcM-UBE2M
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [Complex:R-HSA-8951658] NEDD8-UBA3:NAE1:NEDD8 [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-8951648] NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8951656
summation	[Summation:8951633] After covalent attachment of the first NEDD8 molecule to the...

Referrals

(hasEvent)	[Pathway:R-HSA-8951664] Neddylation
(precedingEvent)	[Reaction:R-HSA-8951751] Doubly neddylated UBA3:NAE1 binds AcM-UBE2M [Reaction:R-HSA-8951766] Doubly neddylated UBA3:NAE1 binds AcM-UBE2F

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