Reactome | COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes

Schema > Reaction > Entries

COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes Show undefined attributes

authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
catalystActivity	[CatalystActivity:8956039] deNEDDylase activity of COP9 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8956038] Rothfels, Karen, 2017-01-13
dbId	8956040
displayName	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
eventOf	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
followingEvent	[Reaction:R-HSA-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome - Homo sapiens
input	[DefinedSet:R-HSA-8956021] NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8956000] Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels [LiteratureReference:8956009] The COP9 signalosome regulates Skp2 levels and proliferation of human cells [LiteratureReference:8955981] Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability [LiteratureReference:8953197] F-box-directed CRL complex assembly and regulation by the CSN and CAND1 [LiteratureReference:8955461] COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase [LiteratureReference:8955995] Structural basis for a reciprocal regulation between SCF and CSN [LiteratureReference:8953164] Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins [LiteratureReference:8955463] CSN- and CAND1-dependent remodelling of the budding yeast SCF complex [LiteratureReference:8955437] CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire [LiteratureReference:8953261] The COP9 signalosome: more than a protease [LiteratureReference:8955979] Deregulation of the COP9 signalosome-cullin-RING ubiquitin-ligase pathway: mechanisms and roles in urological cancers
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
orthologousEvent	[Reaction:R-DDI-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Dictyostelium discoideum [Reaction:R-CEL-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Caenorhabditis elegans [Reaction:R-DME-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Drosophila melanogaster [Reaction:R-GGA-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Gallus gallus [Reaction:R-XTR-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Xenopus tropicalis [Reaction:R-DRE-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Danio rerio [Reaction:R-SSC-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Sus scrofa [Reaction:R-BTA-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Bos taurus [Reaction:R-CFA-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Canis familiaris [Reaction:R-RNO-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Rattus norvegicus [Reaction:R-MMU-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Mus musculus
output	[DefinedSet:R-HSA-8956019] CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] [EntityWithAccessionedSequence:R-HSA-416969] NEDD8 [cytosol]
precedingEvent	[Reaction:R-HSA-8952044] AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex - Homo sapiens [Reaction:R-HSA-8952618] AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex - Homo sapiens [Reaction:R-HSA-8952626] AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex - Homo sapiens [Reaction:R-HSA-8952631] AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8956040
summation	[Summation:8956041] The COP9 signalosome (also known as CSN) is a highly conserv...

Referrals

(hasEvent)	[Pathway:R-HSA-8951664] Neddylation
(precedingEvent)	[Reaction:R-HSA-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome [NegativePrecedingEvent:9767192] Abundant Molecules: COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes [NegativePrecedingEvent:9767189] Futile Cycle: COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes

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