Reactome | Beta-oxidation of pristanoyl-CoA

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Beta-oxidation of pristanoyl-CoA Show undefined attributes

authored	[InstanceEdit:398115] D'Eustachio, P, 2009-03-16 18:50:14
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:389895] D'Eustachio, P, 2009-01-19 22:23:09
dbId	389887
displayName	Beta-oxidation of pristanoyl-CoA
edited	[InstanceEdit:398202] D'Eustachio, P, 2009-03-18 13:33:40
eventOf	[Pathway:R-HSA-390918] Peroxisomal lipid metabolism - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:262733] fatty acid beta-oxidation using acyl-CoA oxidase
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-389897] Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA - Homo sapiens [Reaction:R-HSA-389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - Homo sapiens [Reaction:R-HSA-389891] (2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) - Homo sapiens [Reaction:R-HSA-389986] trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA - Homo sapiens [Reaction:R-HSA-389995] 3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ - Homo sapiens [Reaction:R-HSA-390224] 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA - Homo sapiens [BlackBoxEvent:R-HSA-390276] Conversion of 4,8,12-trimethyltridecanoyl-CoA to 4,8-dimethylnonanoyl-CoA - Homo sapiens [Reaction:R-HSA-390281] 4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH - Homo sapiens [Reaction:R-HSA-390291] acetyl-CoA + carnitine => acetylcarnitine + CoASH - Homo sapiens [Reaction:R-HSA-390304] acetyl-CoA + H2O => acetate + CoASH + H+ - Homo sapiens [Reaction:R-HSA-390284] propionyl-CoA + carnitine => propionylcarnitine + CoASH - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:389650] Biochemistry of mammalian peroxisomes revisited [LiteratureReference:390279] Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids [LiteratureReference:390289] Phytanic acid and pristanic acid are oxidized by sequential peroxisomal and mitochondrial reactions in cultured fibroblasts
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Beta-oxidation of pristanoyl-CoA
orthologousEvent	[Pathway:R-SCE-389887] Beta-oxidation of pristanoyl-CoA - Saccharomyces cerevisiae [Pathway:R-DDI-389887] Beta-oxidation of pristanoyl-CoA - Dictyostelium discoideum [Pathway:R-CEL-389887] Beta-oxidation of pristanoyl-CoA - Caenorhabditis elegans [Pathway:R-DME-389887] Beta-oxidation of pristanoyl-CoA - Drosophila melanogaster [Pathway:R-GGA-389887] Beta-oxidation of pristanoyl-CoA - Gallus gallus [Pathway:R-XTR-389887] Beta-oxidation of pristanoyl-CoA - Xenopus tropicalis [Pathway:R-DRE-389887] Beta-oxidation of pristanoyl-CoA - Danio rerio [Pathway:R-SSC-389887] Beta-oxidation of pristanoyl-CoA - Sus scrofa [Pathway:R-BTA-389887] Beta-oxidation of pristanoyl-CoA - Bos taurus [Pathway:R-CFA-389887] Beta-oxidation of pristanoyl-CoA - Canis familiaris [Pathway:R-RNO-389887] Beta-oxidation of pristanoyl-CoA - Rattus norvegicus [Pathway:R-MMU-389887] Beta-oxidation of pristanoyl-CoA - Mus musculus
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:392190] Jassal, Bijay, 2009-02-27
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-389887
summation	[Summation:389904] Pristanoyl-CoA, generated in the peroxisome by alpha-oxidati...
updateTrackers	[UpdateTracker:9783583] Update Tracker - [Pathway:389887] Beta-oxidation of pristanoyl-CoA - v56:[addHasEvent, updateContainedRLE] [UpdateTracker:9781675] Update Tracker - [Pathway:389887] Beta-oxidation of pristanoyl-CoA - v60:[removeHasEvent] [UpdateTracker:9775153] Update Tracker - [Pathway:389887] Beta-oxidation of pristanoyl-CoA - v80:[updateContainedRLE] [UpdateTracker:9783293] Update Tracker - [Pathway:389887] Beta-oxidation of pristanoyl-CoA - v57:[updateContainedRLE]

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[Pathway:R-HSA-390918] Peroxisomal lipid metabolism

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