Reactome | trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA

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trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA Show undefined attributes

authored	[InstanceEdit:398115] D'Eustachio, P, 2009-03-16 18:50:14
catalystActivity	[CatalystActivity:389989] 3-hydroxyacyl-CoA dehydratase activity of HSD17B4 dimer [peroxisomal matrix]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:389984] D'Eustachio, P, 2009-01-21 23:05:37
dbId	389986
displayName	trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA
edited	[InstanceEdit:398202] D'Eustachio, P, 2009-03-18 13:33:40
eventOf	[Pathway:R-HSA-389887] Beta-oxidation of pristanoyl-CoA - Homo sapiens
followingEvent	[Reaction:R-HSA-389995] 3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ - Homo sapiens
input	[SimpleEntity:R-ALL-141343] H2O [peroxisomal matrix] [SimpleEntity:R-ALL-389894] trans-2,3-dehydropristanoyl-CoA [peroxisomal matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:389997] Mutational spectrum of D-bifunctional protein deficiency and structure-based genotype-phenotype analysis [LiteratureReference:192311] Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase [LiteratureReference:389983] Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein [LiteratureReference:6809276] Identification of the peroxisomal beta-oxidation enzymes involved in the degradation of long-chain dicarboxylic acids
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA
orthologousEvent	[Reaction:R-DDI-389986] trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA - Dictyostelium discoideum [Reaction:R-CEL-389986] trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA - Caenorhabditis elegans [Reaction:R-DME-389986] trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA - Drosophila melanogaster [Reaction:R-GGA-389986] trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA - Gallus gallus [Reaction:R-BTA-389986] trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA - Bos taurus [Reaction:R-CFA-389986] trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA - Canis familiaris [Reaction:R-RNO-389986] trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA - Rattus norvegicus [Reaction:R-MMU-389986] trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA - Mus musculus
output	[SimpleEntity:R-ALL-389982] 3-hydroxypristanoyl-CoA [peroxisomal matrix]
precedingEvent	[Reaction:R-HSA-389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - Homo sapiens [Reaction:R-HSA-389891] (2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) - Homo sapiens
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:392190] Jassal, Bijay, 2009-02-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-389986
summation	[Summation:389998] Peroxisomal HSD17B4 dimer catalyzes the reaction of trans-2,...
updateTrackers	[UpdateTracker:9919418] Update Tracker - [Reaction:389986] trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA - v90:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9919418] Update Tracker - [Reaction:389986] trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA - v90:[modifyText, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-389887] Beta-oxidation of pristanoyl-CoA
(precedingEvent)	[Reaction:R-HSA-389995] 3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+

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