Pristanoyl-CoA, generated in the peroxisome by alpha-oxidation of dietary phytanic acid, is further catabolized by three cycles of peroxisomal beta-oxidation to yield 4,8-dimethylnonanoyl-CoA, acetyl-CoA and two molecules of propionyl-CoA. These molecules in turn are converted to carnitine conjugates, which can be transported to mitochondria (Wanders and Waterham 2006, Verhoeven et al. 1998, Ferdinandusse et al. 1999).
Wanders, RJA, Waterham, HR
Verhoeven, NM, Roe, CR, Kok, RM, Roe, DS, Wanders, RJA, Jakobs, C
IJlst, L, Denis, S, Wanders, RJA, Dacremont, G, Mulders, J, Waterham, HR, Ferdinandusse, S
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