Reactome | 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA

Schema > Reaction > Entries

3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA Show undefined attributes

authored	[InstanceEdit:398115] D'Eustachio, P, 2009-03-16 18:50:14
catalystActivity	[CatalystActivity:192310] propionyl-CoA C2-trimethyltridecanoyltransferase activity of SCP2-1 [peroxisomal matrix]
catalystActivityReference	[CatalystActivityReference:9764593] propionyl-CoA C2-trimethyltridecanoyltransferase activity of SCP2-1 [peroxisomal matrix] Mutations in the gene encoding peroxisomal sterol carrier protein X (SCPx) cause leukencephalopathy with dystonia and motor neuropathy
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:390223] D'Eustachio, P, 2009-01-23 17:38:33
crossReference	[DatabaseIdentifier:12667727] RHEA:10410 [DatabaseIdentifier:9914040] RHEA:10410
dbId	390224
displayName	3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA
edited	[InstanceEdit:398202] D'Eustachio, P, 2009-03-18 13:33:40
eventOf	[Pathway:R-HSA-389887] Beta-oxidation of pristanoyl-CoA - Homo sapiens
followingEvent	[Reaction:R-HSA-390284] propionyl-CoA + carnitine => propionylcarnitine + CoASH - Homo sapiens [BlackBoxEvent:R-HSA-390276] Conversion of 4,8,12-trimethyltridecanoyl-CoA to 4,8-dimethylnonanoyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-389996] 3-ketopristanoyl-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-193514] CoA-SH [peroxisomal matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:390220] Mutations in the gene encoding peroxisomal sterol carrier protein X (SCPx) cause leukencephalopathy with dystonia and motor neuropathy [LiteratureReference:9764596] Sterol carrier protein X (SCPx) is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA 3-oxopristanoyl-CoA + CoA => 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA
orthologousEvent	[Reaction:R-DME-390224] 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA - Drosophila melanogaster [Reaction:R-GGA-390224] 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA - Gallus gallus [Reaction:R-DRE-390224] 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA - Danio rerio [Reaction:R-BTA-390224] 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA - Bos taurus [Reaction:R-CFA-390224] 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA - Canis familiaris [Reaction:R-RNO-390224] 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA - Rattus norvegicus [Reaction:R-MMU-390224] 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA - Mus musculus
output	[SimpleEntity:R-ALL-390002] 4,8,12-trimethyltridecanoyl-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-192314] propionyl CoA [peroxisomal matrix]
precedingEvent	[Reaction:R-HSA-389995] 3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ - Homo sapiens
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:392190] Jassal, Bijay, 2009-02-27
revised	[InstanceEdit:9764595] D'Eustachio, Peter, 2022-02-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-390224
summation	[Summation:390226] Peroxisomal SCPx (Non-specific lipid transfer protein; SCP2)...
updateTrackers	[UpdateTracker:9775205] Update Tracker - [Reaction:390224] 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA - v80:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775205] Update Tracker - [Reaction:390224] 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA - v80:[add_removeLiteratureReference, modifyText]
(precedingEvent)	[Reaction:R-HSA-390284] propionyl-CoA + carnitine => propionylcarnitine + CoASH [BlackBoxEvent:R-HSA-390276] Conversion of 4,8,12-trimethyltridecanoyl-CoA to 4,8-dimethylnonanoyl-CoA
(hasEvent)	[Pathway:R-HSA-389887] Beta-oxidation of pristanoyl-CoA