Reactome | ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA

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ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA Show undefined attributes

authored	[InstanceEdit:398115] D'Eustachio, P, 2009-03-16 18:50:14
catalystActivity	[CatalystActivity:389900] pristanoyl-CoA oxidase activity of ACOX2:FAD, ACOXL:FAD [peroxisomal matrix]
catalystActivityReference	[CatalystActivityReference:9914047] pristanoyl-CoA oxidase activity of ACOX2:FAD, ACOXL:FAD [peroxisomal matrix] The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:389895] D'Eustachio, P, 2009-01-19 22:23:09
crossReference	[DatabaseIdentifier:12667728] RHEA:40460 [DatabaseIdentifier:9914026] RHEA:40460
dbId	389889
displayName	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA
edited	[InstanceEdit:398202] D'Eustachio, P, 2009-03-18 13:33:40
eventOf	[Pathway:R-HSA-389887] Beta-oxidation of pristanoyl-CoA - Homo sapiens
followingEvent	[Reaction:R-HSA-389986] trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-389893] (2S) Pristanoyl-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-113535] O2 [peroxisomal matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:193409] The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney [LiteratureReference:192346] Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (2S)-pristanoyl-CoA + O2 => (2E)-pristenoyl-CoA + H2O2 (2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2)
orthologousEvent	[Reaction:R-SCE-389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - Saccharomyces cerevisiae [Reaction:R-DDI-389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - Dictyostelium discoideum [Reaction:R-CEL-389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - Caenorhabditis elegans [Reaction:R-DME-389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - Drosophila melanogaster [Reaction:R-GGA-389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - Gallus gallus [Reaction:R-XTR-389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - Xenopus tropicalis [Reaction:R-SSC-389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - Sus scrofa [Reaction:R-BTA-389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - Bos taurus [Reaction:R-CFA-389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - Canis familiaris [Reaction:R-RNO-389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - Rattus norvegicus [Reaction:R-MMU-389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - Mus musculus
output	[SimpleEntity:R-ALL-113575] H2O2 [peroxisomal matrix] [SimpleEntity:R-ALL-389894] trans-2,3-dehydropristanoyl-CoA [peroxisomal matrix]
precedingEvent	[Reaction:R-HSA-389897] Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA - Homo sapiens
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:392190] Jassal, Bijay, 2009-02-27
revised	[InstanceEdit:8848539] Jassal, Bijay, 2015-12-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-389889
summation	[Summation:389885] In human liver and kidney tissue, monomeric peroxisomal ACOX...
updateTrackers	[UpdateTracker:9783616] Update Tracker - [Reaction:389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - v56:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783616] Update Tracker - [Reaction:389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - v56:[modifyText]
(hasEvent)	[Pathway:R-HSA-389887] Beta-oxidation of pristanoyl-CoA
(precedingEvent)	[Reaction:R-HSA-389986] trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA