Reactome | ABC-family protein mediated transport

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ABC-family protein mediated transport Show undefined attributes

authored	[InstanceEdit:382535] Gopinathrao, G, 2008-11-23 14:00:06
created	[InstanceEdit:382535] Gopinathrao, G, 2008-11-23 14:00:06
dbId	382556
diseasePathways	[Pathway:R-HSA-5683371] Defective ABCB6 causes MCOPCB7 - Homo sapiens [Pathway:R-HSA-5684045] Defective ABCD1 causes ALD - Homo sapiens [Pathway:R-HSA-5678895] Defective CFTR causes cystic fibrosis - Homo sapiens [Pathway:R-HSA-5690338] Defective ABCC6 causes PXE - Homo sapiens [Pathway:R-HSA-5682294] Defective ABCA12 causes ARCI4B - Homo sapiens [Pathway:R-HSA-5678420] Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome - Homo sapiens [Pathway:R-HSA-5679090] Defective ABCG8 causes GBD4 and sitosterolemia - Homo sapiens [Pathway:R-HSA-5678771] Defective ABCB4 causes PFIC3, ICP3 and GBD1 - Homo sapiens [Pathway:R-HSA-5683678] Defective ABCA3 causes SMDP3 - Homo sapiens [Pathway:R-HSA-5679096] Defective ABCG5 causes sitosterolemia - Homo sapiens
displayName	ABC-family protein mediated transport
edited	[InstanceEdit:387028] Gopinathrao, G, 2008-11-29 15:54:33
eventOf	[TopLevelPathway:R-HSA-382551] Transport of small molecules - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:259583] transmembrane transport
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-383190] HCO3- transport through ion channel - Homo sapiens [Pathway:R-HSA-1369062] ABC transporters in lipid homeostasis - Homo sapiens [Pathway:R-HSA-1369007] Mitochondrial ABC transporters - Homo sapiens [Reaction:R-HSA-1454916] The ABCC family mediates organic anion transport - Homo sapiens [Reaction:R-HSA-5678706] ABCB4 transports PC from plasma membrane to extracellular region - Homo sapiens [BlackBoxEvent:R-HSA-8866851] CFTR transits to the plasma membrane - Homo sapiens [Reaction:R-HSA-5678863] CFTR transports Cl- from cytosol to extracellular region - Homo sapiens [Reaction:R-HSA-1467457] ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region - Homo sapiens [Reaction:R-HSA-1467466] ABCA4 mediates atRAL transport - Homo sapiens [Reaction:R-HSA-5223317] ABCB9 transports peptides from cytosol to lysosomal lumen - Homo sapiens [Reaction:R-HSA-5227009] ABCF1 binds EIF2 - Homo sapiens [Reaction:R-HSA-5678261] KCNJ11:ABCC9 transports K+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-8866551] CFTR binds components of the ERAD machinery for ubiquitination and degradation - Homo sapiens [Reaction:R-HSA-8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - Homo sapiens [Reaction:R-HSA-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol - Homo sapiens [BlackBoxEvent:R-HSA-8866553] misfolded CFTR is degraded by the 26S proteasome - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:387001] Mammalian ABC transporters in health and disease [LiteratureReference:387024] The human ATP-binding cassette (ABC) transporter superfamily [LiteratureReference:1368980] ABC transporters: the power to change
maxDepth	3
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ABC-family protein mediated transport
orthologousEvent	[Pathway:R-MMU-382556] ABC-family protein mediated transport - Mus musculus [Pathway:R-RNO-382556] ABC-family protein mediated transport - Rattus norvegicus [Pathway:R-CFA-382556] ABC-family protein mediated transport - Canis familiaris [Pathway:R-BTA-382556] ABC-family protein mediated transport - Bos taurus [Pathway:R-SSC-382556] ABC-family protein mediated transport - Sus scrofa [Pathway:R-DRE-382556] ABC-family protein mediated transport - Danio rerio [Pathway:R-XTR-382556] ABC-family protein mediated transport - Xenopus tropicalis [Pathway:R-GGA-382556] ABC-family protein mediated transport - Gallus gallus [Pathway:R-DME-382556] ABC-family protein mediated transport - Drosophila melanogaster [Pathway:R-CEL-382556] ABC-family protein mediated transport - Caenorhabditis elegans [Pathway:R-DDI-382556] ABC-family protein mediated transport - Dictyostelium discoideum [Pathway:R-SPO-382556] ABC-family protein mediated transport - Schizosaccharomyces pombe [Pathway:R-SCE-382556] ABC-family protein mediated transport - Saccharomyces cerevisiae [Pathway:R-PFA-382556] ABC-family protein mediated transport - Plasmodium falciparum
releaseDate	2008-12-17
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387472] Matthews, L, 2008-12-02 15:41:53 [InstanceEdit:1502533] D'Eustachio, P, 2011-08-23
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-382556
summation	[Summation:387022] The ATP-binding cassette (ABC) superfamily of active transpo...
updateTrackers	[UpdateTracker:9786831] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v48:[updateIndirectRLE] [UpdateTracker:9784515] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v54:[addHasEvent, updateContainedPathway] [UpdateTracker:9777436] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v71:[removeHasEvent] [UpdateTracker:9788908] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v39:[updateContainedRLE] [UpdateTracker:9790179] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v35:[modifyText, updateContainedRLE] [UpdateTracker:9778265] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v68:[updateContainedRLE] [UpdateTracker:9788248] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v43:[updateContainedRLE] [UpdateTracker:9785121] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v52:[addHasEvent] [UpdateTracker:9787691] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v44:[updateIndirectRLE] [UpdateTracker:9783912] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v55:[addHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9774751] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v81:[updateContainedRLE] [UpdateTracker:9789360] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v38:[add_removeHasEvent, add_removeLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9784616] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v53:[addHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783155] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v57:[addHasEvent, updateContainedPathway] [UpdateTracker:9781552] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v60:[removeHasEvent] [UpdateTracker:9790734] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v33:[addHasEvent, updateContainedRLE]

Referrals

(hasEvent)	[TopLevelPathway:R-HSA-382551] Transport of small molecules
(normalPathway)	[Pathway:R-HSA-5683371] Defective ABCB6 causes MCOPCB7 [Pathway:R-HSA-5684045] Defective ABCD1 causes ALD [Pathway:R-HSA-5678895] Defective CFTR causes cystic fibrosis [Pathway:R-HSA-5690338] Defective ABCC6 causes PXE [Pathway:R-HSA-5682294] Defective ABCA12 causes ARCI4B [Pathway:R-HSA-5678420] Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome [Pathway:R-HSA-5679090] Defective ABCG8 causes GBD4 and sitosterolemia [Pathway:R-HSA-5678771] Defective ABCB4 causes PFIC3, ICP3 and GBD1 [Pathway:R-HSA-5683678] Defective ABCA3 causes SMDP3 [Pathway:R-HSA-5679096] Defective ABCG5 causes sitosterolemia
(updatedInstance)	[UpdateTracker:9786831] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v48:[updateIndirectRLE] [UpdateTracker:9784515] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v54:[addHasEvent, updateContainedPathway] [UpdateTracker:9777436] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v71:[removeHasEvent] [UpdateTracker:9788908] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v39:[updateContainedRLE] [UpdateTracker:9790179] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v35:[modifyText, updateContainedRLE] [UpdateTracker:9778265] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v68:[updateContainedRLE] [UpdateTracker:9788248] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v43:[updateContainedRLE] [UpdateTracker:9785121] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v52:[addHasEvent] [UpdateTracker:9787691] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v44:[updateIndirectRLE] [UpdateTracker:9783912] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v55:[addHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9774751] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v81:[updateContainedRLE] [UpdateTracker:9789360] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v38:[add_removeHasEvent, add_removeLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9784616] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v53:[addHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783155] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v57:[addHasEvent, updateContainedPathway] [UpdateTracker:9781552] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v60:[removeHasEvent] [UpdateTracker:9790734] Update Tracker - [Pathway:382556] ABC-family proteins mediated transport - v33:[addHasEvent, updateContainedRLE]

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