Reactome | VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol

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VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol Show undefined attributes

authored	[InstanceEdit:8866543] Rothfels, Karen, 2016-04-01
category	dissociation
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:8866543] Rothfels, Karen, 2016-04-01
dbId	8866542
displayName	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
edited	[InstanceEdit:8866543] Rothfels, Karen, 2016-04-01
eventOf	[Pathway:R-HSA-382556] ABC-family proteins mediated transport - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8866553] misfolded CFTR is degraded by the 26S proteasome - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] 6 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-8866535] Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5359171] One step at a time: endoplasmic reticulum-associated degradation [LiteratureReference:8866482] Biosynthesis of cystic fibrosis transmembrane conductance regulator
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
orthologousEvent	[Reaction:R-CEL-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol - Caenorhabditis elegans [Reaction:R-GGA-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol - Gallus gallus [Reaction:R-XTR-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol - Xenopus tropicalis [Reaction:R-SSC-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol - Sus scrofa [Reaction:R-BTA-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol - Bos taurus [Reaction:R-CFA-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol - Canis familiaris [Reaction:R-RNO-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol - Rattus norvegicus [Reaction:R-MMU-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol - Mus musculus
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-8866531] ERAD complex [endoplasmic reticulum membrane] 6 × [SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-HSA-8866534] Ub-misfolded nascent CFTR [cytosol]
precedingEvent	[Reaction:R-HSA-8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8868734] D'Eustachio, Peter, 2016-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8866542
summation	[Summation:8866544] Retrotranslocation of the misfolded CFTR likely depends on t...

Referrals

(normalReaction)	[Reaction:R-HSA-8866854] VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol
(precedingEvent)	[BlackBoxEvent:R-HSA-8866553] misfolded CFTR is degraded by the 26S proteasome
(hasEvent)	[Pathway:R-HSA-382556] ABC-family proteins mediated transport