Reactome | CFTR transports Cl- from cytosol to extracellular region

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CFTR transports Cl- from cytosol to extracellular region Show undefined attributes

authored	[InstanceEdit:5678752] Jassal, Bijay, 2015-02-26
catalystActivity	[CatalystActivity:5678923] chloride transmembrane transporter activity of CFTR [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5678752] Jassal, Bijay, 2015-02-26
dbId	5678863
diseaseReaction	[Reaction:R-HSA-5678992] Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region - Homo sapiens [FailedReaction:R-HSA-5678822] Defective CFTR does not transport Cl- from cytosol to extracellular region - Homo sapiens
displayName	CFTR transports Cl- from cytosol to extracellular region
edited	[InstanceEdit:5678752] Jassal, Bijay, 2015-02-26
eventOf	[Pathway:R-HSA-382556] ABC-family protein mediated transport - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-352022] Cl- [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5678961] Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA [LiteratureReference:5678960] CFTR and TMEM16A are separate but functionally related Cl- channels
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	CFTR transports Cl- from cytosol to extracellular region
orthologousEvent	[Reaction:R-PFA-5678863] CFTR transports Cl- from cytosol to extracellular region - Plasmodium falciparum [Reaction:R-SCE-5678863] CFTR transports Cl- from cytosol to extracellular region - Saccharomyces cerevisiae [Reaction:R-SPO-5678863] CFTR transports Cl- from cytosol to extracellular region - Schizosaccharomyces pombe [Reaction:R-DDI-5678863] CFTR transports Cl- from cytosol to extracellular region - Dictyostelium discoideum [Reaction:R-CEL-5678863] CFTR transports Cl- from cytosol to extracellular region - Caenorhabditis elegans [Reaction:R-DME-5678863] CFTR transports Cl- from cytosol to extracellular region - Drosophila melanogaster [Reaction:R-GGA-5678863] CFTR transports Cl- from cytosol to extracellular region - Gallus gallus [Reaction:R-XTR-5678863] CFTR transports Cl- from cytosol to extracellular region - Xenopus tropicalis [Reaction:R-DRE-5678863] CFTR transports Cl- from cytosol to extracellular region - Danio rerio [Reaction:R-SSC-5678863] CFTR transports Cl- from cytosol to extracellular region - Sus scrofa [Reaction:R-BTA-5678863] CFTR transports Cl- from cytosol to extracellular region - Bos taurus [Reaction:R-CFA-5678863] CFTR transports Cl- from cytosol to extracellular region - Canis familiaris [Reaction:R-RNO-5678863] CFTR transports Cl- from cytosol to extracellular region - Rattus norvegicus [Reaction:R-MMU-5678863] CFTR transports Cl- from cytosol to extracellular region - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-188972] Cl- [extracellular region] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-8866851] CFTR transits to the plasma membrane - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690296] Moitra, Karobi, 2015-04-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5678863
summation	[Summation:5678848] Cystic fibrosis transmembrane conductance regulator (CFTR) i...

Referrals

(normalReaction)	[Reaction:R-HSA-5678992] Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region [FailedReaction:R-HSA-5678822] Defective CFTR does not transport Cl- from cytosol to extracellular region
(hasEvent)	[Pathway:R-HSA-382556] ABC-family protein mediated transport

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