Reactome | RNF5 and RNF185 ubiquitinate misfolded CFTR

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RNF5 and RNF185 ubiquitinate misfolded CFTR Show undefined attributes

authored	[InstanceEdit:8866556] Rothfels, Karen, 2016-04-01
catalystActivity	[CatalystActivity:8866547] ubiquitin protein ligase activity of misfolded CFTR:ERAD complex [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:8866543] Rothfels, Karen, 2016-04-01
dbId	8866546
diseaseReaction	[Reaction:R-HSA-8866856] RNF5 and RNF185 ubiquitinate CFTR F508del - Homo sapiens
displayName	RNF5 and RNF185 ubiquitinate misfolded CFTR
edited	[InstanceEdit:8866866] Rothfels, Karen, 2016-04-04
eventOf	[Pathway:R-HSA-382556] ABC-family protein mediated transport - Homo sapiens
followingEvent	[Reaction:R-HSA-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol - Homo sapiens
input	[Complex:R-HSA-8866538] misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8866505] RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR) [LiteratureReference:8866509] Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RNF5 and RNF185 ubiquitinate misfolded CFTR
orthologousEvent	[Reaction:R-CEL-8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - Caenorhabditis elegans [Reaction:R-DME-8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - Drosophila melanogaster [Reaction:R-GGA-8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - Gallus gallus [Reaction:R-XTR-8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - Xenopus tropicalis [Reaction:R-DRE-8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - Danio rerio [Reaction:R-SSC-8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - Sus scrofa [Reaction:R-BTA-8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - Bos taurus [Reaction:R-CFA-8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - Canis familiaris [Reaction:R-RNO-8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - Rattus norvegicus [Reaction:R-MMU-8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - Mus musculus
output	[Complex:R-HSA-8866535] Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8868734] D'Eustachio, Peter, 2016-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8866546
summation	[Summation:8866545] RNF5 and RNF185 ubiquitinate misfolded CFTR as part of the r...
updateTrackers	[UpdateTracker:9778389] Update Tracker - [Reaction:8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - v68:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9778389] Update Tracker - [Reaction:8866546] RNF5 and RNF185 ubiquitinate misfolded CFTR - v68:[add_removeInput]
(normalReaction)	[Reaction:R-HSA-8866856] RNF5 and RNF185 ubiquitinate CFTR F508del
(hasEvent)	[Pathway:R-HSA-382556] ABC-family protein mediated transport
(precedingEvent)	[Reaction:R-HSA-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol