Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region
Show undefined attributes
Go to Details
authored
[InstanceEdit:1467435] Jassal, Bijay, 2011-08-01
catalystActivity
[CatalystActivity:1467472] ATPase-coupled transmembrane transporter activity of ABCA8/B1/B5 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created
[InstanceEdit:1467435] Jassal, Bijay, 2011-08-01
dbId
1467457
displayName
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region
edited
[InstanceEdit:1467435] Jassal, Bijay, 2011-08-01
eventOf
[Pathway:R-HSA-382556] ABC-family proteins mediated transport - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[DefinedSet:R-ALL-9659678] xenobiotics (ABCB1) [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1467460] Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification
[LiteratureReference:1467450] ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma
[LiteratureReference:1467441] Functional analysis of ABCA8, a new drug transporter
[LiteratureReference:9659837] Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis
[LiteratureReference:9659871] Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity
[LiteratureReference:9659888] P-glycoprotein mediates profound resistance to bisantrene
[LiteratureReference:9659886] Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine
[LiteratureReference:9659907] Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia
[LiteratureReference:9659900] Interaction of docetaxel ("Taxotere") with human P-glycoprotein
[LiteratureReference:9659930] A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells
[LiteratureReference:9659916] Multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 complementary DNA
[LiteratureReference:9659932] Inhibition of MDR1 expression by retinol treatment increases sensitivity to etoposide (VP16) in human neoplasic cell line
[LiteratureReference:9659938] Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux
[LiteratureReference:9659944] Kinetics of P-glycoprotein-mediated efflux of paclitaxel
[LiteratureReference:9659947] P-glycoprotein but not topoisomerase II and glutathione-S-transferase-pi accounts for enhanced intracellular drug-resistance in LoVo MDR human cell lines
[LiteratureReference:9659959] Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody
[LiteratureReference:9660713] Influx and efflux transport as determinants of melphalan cytotoxicity: Resistance to melphalan in MDR1 overexpressing tumor cell lines
[LiteratureReference:9660730] Temozolomide competes for P-glycoprotein and contributes to chemoresistance in glioblastoma cells
[LiteratureReference:9660758] P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice
[LiteratureReference:9660747] MDR1 polymorphism role in patients treated with cetuximab and irinotecan in irinotecan refractory colorectal cancer
[LiteratureReference:9660779] Identification of budesonide and prednisone as substrates of the intestinal drug efflux pump P-glycoprotein
[LiteratureReference:9660949] Structural determinants of P-glycoprotein-mediated transport of glucocorticoids
[LiteratureReference:9660964] Polymorphisms in the multidrug-resistance 1 gene related to glucocorticoid response in rheumatoid arthritis treatment
[LiteratureReference:9660934] The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone
[LiteratureReference:9660948] Profound differences in the transport of steroids by two mouse P-glycoproteins
[LiteratureReference:9660941] Pharmacokinetics of erythromycin in rabbit corneas after single-dose infusion: role of P-glycoprotein as a barrier to in vivo ocular drug absorption
[LiteratureReference:9660947] Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays
[LiteratureReference:9661286] Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo
[LiteratureReference:9770936] Is the emperor wearing shorts? The published structures of ABC transporters
[LiteratureReference:9770935] Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein
modified
[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region
orthologousEvent
[Reaction:R-PFA-1467457] ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region - Plasmodium falciparum
[Reaction:R-MMU-1467457] ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region - Mus musculus
[Reaction:R-RNO-1467457] ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region - Rattus norvegicus
[Reaction:R-CFA-1467457] ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region - Canis familiaris
[Reaction:R-BTA-1467457] ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region - Bos taurus
[Reaction:R-SSC-1467457] ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region - Sus scrofa
[Reaction:R-GGA-1467457] ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region - Gallus gallus
[Reaction:R-DDI-1467457] ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region - Dictyostelium discoideum
[Reaction:R-SPO-1467457] ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region - Schizosaccharomyces pombe
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[SimpleEntity:R-ALL-29372] Pi [cytosol]
[DefinedSet:R-ALL-9659675] xenobiotics (ABCB1) [extracellular region]
releaseDate
2011-09-20
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1502533] D'Eustachio, P, 2011-08-23
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1467457
summation
[Summation:1467440] Some members of the ABC transporter superfamily are able to ...
Referrals
(hasEvent)
[Pathway:R-HSA-382556] ABC-family proteins mediated transport
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text