Reactome | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)

Schema > Pathway > Entries

Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Show undefined attributes

authored	[InstanceEdit:421433] May, B, 2009-05-18 21:31:59
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen [Compartment:1462052] secretory granule lumen [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:381785] May, B, 2008-11-20 11:59:49
dbId	381771
displayName	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
edited	[InstanceEdit:435259] May, B, 2009-09-09
eventOf	[Pathway:R-HSA-400508] Incretin synthesis, secretion, and inactivation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:9037509] glucagon processing
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-381799] Synthesis of Preproglucagon in intestinal L cells - Homo sapiens [Reaction:R-HSA-400459] Signal peptidase hydrolyzes preproGLP-1 to proGLP-1 - Homo sapiens [BlackBoxEvent:R-HSA-421416] Proglucagon translocates from the ER Lumen to secretory granules - Homo sapiens [BlackBoxEvent:R-HSA-381798] PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 - Homo sapiens [BlackBoxEvent:R-HSA-383313] Glucagon-like Peptide 1 is secreted from intestinal L cells - Homo sapiens [Reaction:R-HSA-9023633] DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) - Homo sapiens [Reaction:R-HSA-9023632] DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) - Homo sapiens [Reaction:R-HSA-9709179] DPP4 binds DPP4 inhibitors - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:381800] The physiology of glucagon-like peptide 1 [LiteratureReference:382289] Biology of incretins: GLP-1 and GIP [LiteratureReference:400458] The role of incretins in glucose homeostasis and diabetes treatment [LiteratureReference:508128] A human cellular model for studying the regulation of glucagon-like peptide-1 secretion [LiteratureReference:508119] Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man [LiteratureReference:879882] Incretins and other peptides in the treatment of diabetes
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
orthologousEvent	[Pathway:R-SCE-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Saccharomyces cerevisiae [Pathway:R-SPO-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Schizosaccharomyces pombe [Pathway:R-DDI-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Dictyostelium discoideum [Pathway:R-CEL-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Caenorhabditis elegans [Pathway:R-GGA-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Gallus gallus [Pathway:R-XTR-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Xenopus tropicalis [Pathway:R-DRE-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Danio rerio [Pathway:R-SSC-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Sus scrofa [Pathway:R-BTA-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Bos taurus [Pathway:R-CFA-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Canis familiaris [Pathway:R-RNO-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Rattus norvegicus [Pathway:R-MMU-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Mus musculus
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:879883] Bloom, SR, 2010-06-24
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-381771
summation	[Summation:381791] In L cells of the intestine the transcription factors TCF-4 ...
updateTrackers	[UpdateTracker:9775930] Update Tracker - [Pathway:381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - v78:[updateContainedRLE] [UpdateTracker:9787688] Update Tracker - [Pathway:381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - v44:[updateContainedRLE] [UpdateTracker:9774700] Update Tracker - [Pathway:381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - v81:[addHasEvent] [UpdateTracker:9785405] Update Tracker - [Pathway:381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - v52:[updateContainedRLE] [UpdateTracker:9780438] Update Tracker - [Pathway:381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - v63:[add_removeHasEvent]

Referrals

(updatedInstance)

[UpdateTracker:9775930] Update Tracker - [Pathway:381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - v78:[updateContainedRLE]
[UpdateTracker:9787688] Update Tracker - [Pathway:381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - v44:[updateContainedRLE]
[UpdateTracker:9774700] Update Tracker - [Pathway:381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - v81:[addHasEvent]
[UpdateTracker:9785405] Update Tracker - [Pathway:381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - v52:[updateContainedRLE]
[UpdateTracker:9780438] Update Tracker - [Pathway:381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - v63:[add_removeHasEvent]

(hasEvent)

[Pathway:R-HSA-400508] Incretin synthesis, secretion, and inactivation

Cite Us!