Reactome | Synthesis of Preproglucagon in intestinal L cells

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Synthesis of Preproglucagon in intestinal L cells Show undefined attributes

authored	[InstanceEdit:421433] May, B, 2009-05-18 21:31:59
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:381785] May, B, 2008-11-20 11:59:49
dbId	381799
displayName	Synthesis of Preproglucagon in intestinal L cells
edited	[InstanceEdit:435259] May, B, 2009-09-09
eventOf	[Pathway:R-HSA-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Homo sapiens
followingEvent	[Reaction:R-HSA-400459] Signal peptidase hydrolyzes preproGLP-1 to proGLP-1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5653043] GCG gene [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:508119] Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man [LiteratureReference:508110] Glucagon- and PP-related peptides of intestinal L cells and pancreatic/gastric A or PP cells. Possible interrelationships of peptides and cells during evolution, fetal development and tumor growth [LiteratureReference:508128] A human cellular model for studying the regulation of glucagon-like peptide-1 secretion [LiteratureReference:508117] Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon [LiteratureReference:508114] Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP [LiteratureReference:382396] Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells [LiteratureReference:382418] Role of leptin in the regulation of glucagon-like peptide-1 secretion
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Synthesis of Preproglucagon in intestinal L cells
output	[EntityWithAccessionedSequence:R-HSA-400456] GCG(1-180) [endoplasmic reticulum lumen]
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-391470] Positive gene expression regulation by 'hTCF-4:Beta-catenin [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-400473] Positive gene expression regulation by 'CDX2 [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-400535] Positive gene expression regulation by 'PAX6 [nucleoplasm]'
regulationReference	[RegulationReference:9642794] Positive gene expression regulation by 'PAX6 [nucleoplasm]' The role of incretins in glucose homeostasis and diabetes treatment [RegulationReference:9642798] Positive gene expression regulation by 'CDX2 [nucleoplasm]' Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells [RegulationReference:9643046] Positive gene expression regulation by 'hTCF-4:Beta-catenin [nucleoplasm]' Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:879883] Bloom, SR, 2010-06-24
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-381799
summation	[Summation:382458] TCF-4 and Beta-Catenin form a heterodimer that bind the G2 e... [Summation:382287] Beta-catenin:TCF-4 bound at the promoter of the GCG gene rec...
updateTrackers	[UpdateTracker:9785355] Update Tracker - [BlackBoxEvent:381799] Synthesis of Preproglucagon in intestinal L cells - v52:[addInput] [UpdateTracker:9775923] Update Tracker - [BlackBoxEvent:381799] Synthesis of Preproglucagon in intestinal L cells - v78:[addSummation] [UpdateTracker:9787628] Update Tracker - [BlackBoxEvent:381799] Synthesis of Preproglucagon in intestinal L cells - v44:[add_removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9785355] Update Tracker - [BlackBoxEvent:381799] Synthesis of Preproglucagon in intestinal L cells - v52:[addInput] [UpdateTracker:9775923] Update Tracker - [BlackBoxEvent:381799] Synthesis of Preproglucagon in intestinal L cells - v78:[addSummation] [UpdateTracker:9787628] Update Tracker - [BlackBoxEvent:381799] Synthesis of Preproglucagon in intestinal L cells - v44:[add_removeRegulator]
(hasEvent)	[Pathway:R-HSA-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
(precedingEvent)	[Reaction:R-HSA-400459] Signal peptidase hydrolyzes preproGLP-1 to proGLP-1

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