Reactome | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)

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Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Show undefined attributes

compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen [Compartment:1462052] secretory granule lumen [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10223607
displayName	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
eventOf	[Pathway:R-RNO-400508] Incretin synthesis, secretion, and inactivation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:9037509] glucagon processing
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-RNO-421416] Proglucagon translocates from the ER Lumen to secretory granules - Rattus norvegicus [BlackBoxEvent:R-RNO-383313] Glucagon-like Peptide 1 is secreted from intestinal L cells - Rattus norvegicus [Reaction:R-RNO-9023633] DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) - Rattus norvegicus [Reaction:R-RNO-9023632] DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) - Rattus norvegicus [Reaction:R-RNO-9709179] DPP4 binds DPP4 inhibitors - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-381771
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-400508] Incretin synthesis, secretion, and inactivation
(inferredTo)	[Pathway:R-HSA-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)

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