Reactome | PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1

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PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 Show undefined attributes

authored	[InstanceEdit:421433] May, B, 2009-05-18 21:31:59
catalystActivity	[CatalystActivity:378987] serine-type endopeptidase activity of PC1:calcium cofactor [secretory granule lumen]
category	omitted
compartment	[Compartment:1462052] secretory granule lumen
created	[InstanceEdit:381785] May, B, 2008-11-20 11:59:49
dbId	381798
displayName	PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1
edited	[InstanceEdit:435259] May, B, 2009-09-09
eventOf	[Pathway:R-HSA-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-383313] Glucagon-like Peptide 1 is secreted from intestinal L cells - Homo sapiens
inferredFrom	[Reaction:R-MMU-508217] Pcsk1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (7-36) - Mus musculus [Reaction:R-MMU-508205] Pcsk1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (7-37) - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-421418] GCG(21-180) [secretory granule lumen]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:879884] Expression, purification, and PC1-mediated processing of human proglucagon, glicentin, and major proglucagon fragment
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1
output	[DefinedSet:R-HSA-879886] mature GLP-1 [secretory granule lumen]
precedingEvent	[BlackBoxEvent:R-HSA-421416] Proglucagon translocates from the ER Lumen to secretory granules - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:879883] Bloom, SR, 2010-06-24
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-381798
summation	[Summation:381773] In secretory granules of intestinal L cells, proglucagon is ...
updateTrackers	[UpdateTracker:9787932] Update Tracker - [BlackBoxEvent:381798] PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 - v44:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9787932] Update Tracker - [BlackBoxEvent:381798] PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 - v44:[add_removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
(precedingEvent)	[BlackBoxEvent:R-HSA-383313] Glucagon-like Peptide 1 is secreted from intestinal L cells
(inferredTo)	[Reaction:R-MMU-508217] Pcsk1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (7-36) [Reaction:R-MMU-508205] Pcsk1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (7-37)

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