Reactome | DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)

Schema > Reaction > Entries

DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) Show undefined attributes

authored	[InstanceEdit:421433] May, B, 2009-05-18 21:31:59
catalystActivity	[CatalystActivity:400498] serine-type endopeptidase activity of DPP4(39-766) [extracellular region]
catalystActivityReference	[CatalystActivityReference:9644120] serine-type endopeptidase activity of DPP4(39-766) [extracellular region] Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9023634] May, Bruce, 2017-09-28
dbId	9023632
deleted	[Deleted:9023669] Deletion of instance: 400495
displayName	DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)
edited	[InstanceEdit:435259] May, B, 2009-09-09
eventOf	[Pathway:R-HSA-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Homo sapiens
input	[DefinedSet:R-HSA-381662] mature GLP1 [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:508144] Investigation of glucose-dependent insulinotropic polypeptide-(1-42) and glucagon-like peptide-1-(7-36) degradation in vitro by dipeptidyl peptidase IV using matrix-assisted laser desorption/ionization-time of flight mass spectrometry. A novel kinetic approach [LiteratureReference:508106] Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo [LiteratureReference:508103] Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum [LiteratureReference:508105] Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme [LiteratureReference:400541] Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)
orthologousEvent	[Reaction:R-GGA-9023632] DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) - Gallus gallus [Reaction:R-DRE-9023632] DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) - Danio rerio [Reaction:R-BTA-9023632] DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) - Bos taurus [Reaction:R-CFA-9023632] DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) - Canis familiaris [Reaction:R-RNO-9023632] DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) - Rattus norvegicus [Reaction:R-MMU-9023632] DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) - Mus musculus
output	[DefinedSet:R-HSA-400520] GLP-1 (Cleaved at N-terminus) [extracellular region]
precedingEvent	[BlackBoxEvent:R-HSA-383313] Glucagon-like Peptide 1 is secreted from intestinal L cells - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:879883] Bloom, SR, 2010-06-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9023632
summation	[Summation:400539] Dipeptidyl Peptidase IV (DPP4) cleaves 2 amino acids from th...

Referrals

(replacementInstances)	[Deleted:9023669] Deletion of instance: 400495
(hasEvent)	[Pathway:R-HSA-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)

Cite Us!