Reactome | DPP4 binds DPP4 inhibitors

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DPP4 binds DPP4 inhibitors Show undefined attributes

authored	[InstanceEdit:9709186] Jassal, Bijay, 2020-12-10
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9709186] Jassal, Bijay, 2020-12-10
dbId	9709179
definition	Inhibition
displayName	DPP4 binds DPP4 inhibitors
edited	[InstanceEdit:9709186] Jassal, Bijay, 2020-12-10 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Homo sapiens
input	[DefinedSet:R-ALL-9709178] DPP4 inhibitors [extracellular region] [EntityWithAccessionedSequence:R-HSA-400517] DPP4(39-766) [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9709225] Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes [LiteratureReference:9709216] Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes [LiteratureReference:9709228] Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	DPP4 binds DPP4 inhibitors
orthologousEvent	[Reaction:R-SCE-9709179] DPP4 binds DPP4 inhibitors - Saccharomyces cerevisiae [Reaction:R-SPO-9709179] DPP4 binds DPP4 inhibitors - Schizosaccharomyces pombe [Reaction:R-DDI-9709179] DPP4 binds DPP4 inhibitors - Dictyostelium discoideum [Reaction:R-CEL-9709179] DPP4 binds DPP4 inhibitors - Caenorhabditis elegans [Reaction:R-GGA-9709179] DPP4 binds DPP4 inhibitors - Gallus gallus [Reaction:R-DRE-9709179] DPP4 binds DPP4 inhibitors - Danio rerio [Reaction:R-BTA-9709179] DPP4 binds DPP4 inhibitors - Bos taurus [Reaction:R-CFA-9709179] DPP4 binds DPP4 inhibitors - Canis familiaris [Reaction:R-RNO-9709179] DPP4 binds DPP4 inhibitors - Rattus norvegicus [Reaction:R-MMU-9709179] DPP4 binds DPP4 inhibitors - Mus musculus
output	[Complex:R-HSA-9709184] DPP4:DPP4 inhibitors [extracellular region]
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9709179
summation	[Summation:9709229] Dipeptidyl peptidase-4 (DPP4) is a serine exopeptidase that ...

Referrals

(hasEvent)

[Pathway:R-HSA-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)