Reactome | Translation of ATF4

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Translation of ATF4 Show undefined attributes

authored	[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:381159] May, B, 2008-11-19 16:17:44
dbId	381128
displayName	Translation of ATF4
edited	[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
eventOf	[Pathway:R-HSA-9648895] Response of EIF2AK1 (HRI) to heme deficiency - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9654792] Expression of GRB10 - Homo sapiens [Reaction:R-HSA-9653893] ATF4, CEBPB, and ATF3 bind the CHAC1 promoter - Homo sapiens [Reaction:R-HSA-9655086] ATF4 binds the DDIT3 promoter - Homo sapiens [Reaction:R-HSA-9654752] ATF4 binds the PPP1R15A (GADD34) promoter - Homo sapiens [Reaction:R-HSA-9653742] ATF4 and a CEBP protein bind the ATF5 promoter - Homo sapiens [BlackBoxEvent:R-HSA-1791095] Expression of HERPUD - Homo sapiens [BlackBoxEvent:R-HSA-1791056] Expression of CCL2 - Homo sapiens [BlackBoxEvent:R-HSA-1791180] Expression of IGFBP1 - Homo sapiens [BlackBoxEvent:R-HSA-517731] Expression of IL-8 - Homo sapiens [BlackBoxEvent:R-HSA-1791118] Expression of ASNS (Asparagine Synthetase) - Homo sapiens [Reaction:R-HSA-9635915] ATF4 and CEBPB,CEBPG bind the ASNS gene - Homo sapiens [Reaction:R-HSA-9635936] ATF4 binds the CEBPB gene - Homo sapiens [Reaction:R-HSA-9635804] ATF4 and phospho-ATF2 bind the DDIT3 promoter - Homo sapiens [Reaction:R-HSA-9635927] ATF4 and a CEBP protein bind the TRIB3 promoter - Homo sapiens [BlackBoxEvent:R-HSA-1791173] Expression of ATF3 - Homo sapiens [Reaction:R-HSA-9635892] ATF4 binds the ATF3 gene - Homo sapiens [BlackBoxEvent:R-HSA-1791107] Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9635380] Translation of Atf4 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-9661812] ATF4 mRNA [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:535582] Activating transcription factor 4 is translationally regulated by hypoxic stress [LiteratureReference:9635376] Eukaryotic Initiation Factor 5B (eIF5B) Cooperates with eIF1A and eIF5 to Facilitate uORF2-Mediated Repression of ATF4 Translation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Translation of ATF4
output	[EntityWithAccessionedSequence:R-HSA-381016] ATF4 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - Homo sapiens [Reaction:R-HSA-9633008] p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 - Homo sapiens [Reaction:R-HSA-9648888] p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-420845] Positive regulation by 'p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]'
regulationReference	[RegulationReference:9641495] Positive regulation by 'p-S52-EIF2A1:EIF2A2:EIF2A3 [cytosol]' Activating transcription factor 4 is translationally regulated by hypoxic stress
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 [InstanceEdit:638652] Urano, F, 2010-04-30 [InstanceEdit:9661246] Bruhat, Alain, 2019-09-15 [InstanceEdit:9664254] Chen, Jane-Jane, 2019-10-22 [InstanceEdit:9668172] Staschke, Kirk A, 2019-11-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-381128
summation	[Summation:381113] ATF4 mRNA is translated to yield ATF4 protein, which then tr...
updateTrackers	[UpdateTracker:9790552] Update Tracker - [BlackBoxEvent:381128] Translation of ATF4 - v33:[add_removeLiteratureReference, add_removeRegulator, modifyText] [UpdateTracker:9778597] Update Tracker - [BlackBoxEvent:381128] Translation of ATF4 - v68:[addLiteratureReference, add_removeRegulator, modifyText] [UpdateTracker:9785736] Update Tracker - [BlackBoxEvent:381128] Translation of ATF4 - v51:[addInput] [UpdateTracker:9777571] Update Tracker - [BlackBoxEvent:381128] Translation of ATF4 - v70:[modifyText, removeLiteratureReference] [UpdateTracker:9777480] Update Tracker - [BlackBoxEvent:381128] Translation of ATF4 - v71:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9790552] Update Tracker - [BlackBoxEvent:381128] Translation of ATF4 - v33:[add_removeLiteratureReference, add_removeRegulator, modifyText] [UpdateTracker:9778597] Update Tracker - [BlackBoxEvent:381128] Translation of ATF4 - v68:[addLiteratureReference, add_removeRegulator, modifyText] [UpdateTracker:9785736] Update Tracker - [BlackBoxEvent:381128] Translation of ATF4 - v51:[addInput] [UpdateTracker:9777571] Update Tracker - [BlackBoxEvent:381128] Translation of ATF4 - v70:[modifyText, removeLiteratureReference] [UpdateTracker:9777480] Update Tracker - [BlackBoxEvent:381128] Translation of ATF4 - v71:[add_removeInput]
(precedingEvent)	[BlackBoxEvent:R-HSA-9654792] Expression of GRB10 [Reaction:R-HSA-9653893] ATF4, CEBPB, and ATF3 bind the CHAC1 promoter [Reaction:R-HSA-9655086] ATF4 binds the DDIT3 promoter [Reaction:R-HSA-9654752] ATF4 binds the PPP1R15A (GADD34) promoter [Reaction:R-HSA-9653742] ATF4 and a CEBP protein bind the ATF5 promoter [BlackBoxEvent:R-HSA-1791095] Expression of HERPUD [BlackBoxEvent:R-HSA-1791056] Expression of CCL2 [BlackBoxEvent:R-HSA-1791107] Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein [BlackBoxEvent:R-HSA-1791180] Expression of IGFBP1 [BlackBoxEvent:R-HSA-517731] Expression of IL-8 [BlackBoxEvent:R-HSA-1791118] Expression of ASNS (Asparagine Synthetase) [Reaction:R-HSA-9635915] ATF4 and CEBPB,CEBPG bind the ASNS gene [Reaction:R-HSA-9635936] ATF4 binds the CEBPB gene [Reaction:R-HSA-9635804] ATF4 and phospho-ATF2 bind the DDIT3 promoter [Reaction:R-HSA-9635927] ATF4 and a CEBP protein bind the TRIB3 promoter [BlackBoxEvent:R-HSA-1791173] Expression of ATF3 [Reaction:R-HSA-9635892] ATF4 binds the ATF3 gene
(hasEvent)	[Pathway:R-HSA-9648895] Response of EIF2AK1 (HRI) to heme deficiency [Pathway:R-HSA-381042] PERK regulates gene expression [Pathway:R-HSA-9633012] Response of EIF2AK4 (GCN2) to amino acid deficiency
(inferredTo)	[BlackBoxEvent:R-MMU-9635380] Translation of Atf4

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