Reactome | Response of EIF2AK4 (GCN2) to amino acid deficiency

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Response of EIF2AK4 (GCN2) to amino acid deficiency Show undefined attributes

authored	[InstanceEdit:9633017] May, Bruce, 2018-12-27
created	[InstanceEdit:9633011] May, Bruce, 2018-12-27
dbId	9633012
displayName	Response of EIF2AK4 (GCN2) to amino acid deficiency
doi	10.3180/R-HSA-9633012.1
edited	[InstanceEdit:9633017] May, Bruce, 2018-12-27
eventOf	[Pathway:R-HSA-9711097] Cellular response to starvation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:258409] cellular response to amino acid starvation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9633005] EIF2AK4 (GCN2) binds tRNA - Homo sapiens [Reaction:R-HSA-9633742] EIF2AK4 (GCN2) dimer autophosphorylates - Homo sapiens [Reaction:R-HSA-9633008] p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 - Homo sapiens [BlackBoxEvent:R-HSA-381128] Translation of ATF4 - Homo sapiens [BlackBoxEvent:R-HSA-9650722] Translation of DDIT3 - Homo sapiens [Reaction:R-HSA-9635804] ATF4 and phospho-ATF2 bind the DDIT3 promoter - Homo sapiens [BlackBoxEvent:R-HSA-9644926] Transcription of DDIT3 (CHOP, GADD153) in response to amino acid deficiency - Homo sapiens [Reaction:R-HSA-9635892] ATF4 binds the ATF3 gene - Homo sapiens [BlackBoxEvent:R-HSA-1791173] Expression of ATF3 - Homo sapiens [Reaction:R-HSA-9635915] ATF4 and CEBPB,CEBPG bind the ASNS gene - Homo sapiens [BlackBoxEvent:R-HSA-1791118] Expression of ASNS (Asparagine Synthetase) - Homo sapiens [Reaction:R-HSA-9635936] ATF4 binds the CEBPB gene - Homo sapiens [BlackBoxEvent:R-HSA-9635918] Expression of CEBPB in response to stress - Homo sapiens [Reaction:R-HSA-9635927] ATF4 and a CEBP protein bind the TRIB3 promoter - Homo sapiens [BlackBoxEvent:R-HSA-9635912] Expression of TRIB3 in response to stress - Homo sapiens [Reaction:R-HSA-9634669] IMPACT binds GCN1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:9633771] Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR [LiteratureReference:9633826] Amino acid homeostasis and signalling in mammalian cells and organisms [LiteratureReference:9635265] The eIF2? kinases: their structures and functions [LiteratureReference:9635270] Coping with stress: eIF2 kinases and translational control [LiteratureReference:9635264] The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress [LiteratureReference:9635263] GCN2 whets the appetite for amino acids [LiteratureReference:9635215] Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex [LiteratureReference:9635261] The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores [LiteratureReference:9635304] Re-examination of Dietary Amino Acid Sensing Reveals a GCN2-Independent Mechanism [LiteratureReference:9645377] Measuring the Ability of Mice to Sense Dietary Essential Amino Acid Deficiency: The Importance of Amino Acid Status and Timing [LiteratureReference:9645572] Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells [LiteratureReference:9645571] The transcription factor network associated with the amino acid response in mammalian cells [LiteratureReference:9645567] Role of eIF2? Kinases in Translational Control and Adaptation to Cellular Stress [LiteratureReference:5672805] Regulation of translation initiation in eukaryotes: mechanisms and biological targets [LiteratureReference:9645575] Translational control by 5'-untranslated regions of eukaryotic mRNAs [LiteratureReference:9645574] Molecular mechanisms involved in the adaptation to amino acid limitation in mammals [LiteratureReference:9645578] Keeping the eIF2 alpha kinase Gcn2 in check [LiteratureReference:9645582] The integrated stress response [LiteratureReference:381002] Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Response of EIF2AK4 (GCN2) to amino acid deficiency
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9661246] Bruhat, Alain, 2019-09-15 [InstanceEdit:9668172] Staschke, Kirk A, 2019-11-20
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9633012
summation	[Summation:9633728] EIF2AK4 (GCN2) senses amino acid deficiency by binding uncha...
updateTrackers	[UpdateTracker:9777315] Update Tracker - [Pathway:9633012] Response of EIF2AK4 (GCN2) to amino acid deficiency - v72:[modifyText, updateContainedRLE] [UpdateTracker:9775696] Update Tracker - [Pathway:9633012] Response of EIF2AK4 (GCN2) to amino acid deficiency - v78:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9777315] Update Tracker - [Pathway:9633012] Response of EIF2AK4 (GCN2) to amino acid deficiency - v72:[modifyText, updateContainedRLE] [UpdateTracker:9775696] Update Tracker - [Pathway:9633012] Response of EIF2AK4 (GCN2) to amino acid deficiency - v78:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-9711097] Cellular response to starvation
(hasEncapsulatedEvent)	[Pathway:R-HSA-9818035] NFE2L2 regulating ER-stress associated genes

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