Reactome | EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK

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EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK Show undefined attributes

authored	[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
catalystActivity	[CatalystActivity:381179] protein serine/threonine kinase activity of PERK dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:381159] May, B, 2008-11-19 16:17:44
dbId	381111
displayName	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK
edited	[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
eventOf	[Pathway:R-HSA-381042] PERK regulates gene expression - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-381128] Translation of ATF4 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:381208] Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells [LiteratureReference:535547] Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress [LiteratureReference:535531] Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha [LiteratureReference:535585] Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases [LiteratureReference:535497] Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha [LiteratureReference:381145] PERK in the life and death of the pancreatic beta-cell
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK
orthologousEvent	[Reaction:R-CEL-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - Caenorhabditis elegans [Reaction:R-DME-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - Drosophila melanogaster [Reaction:R-GGA-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - Gallus gallus [Reaction:R-XTR-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - Xenopus tropicalis [Reaction:R-SSC-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - Sus scrofa [Reaction:R-BTA-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - Bos taurus [Reaction:R-CFA-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - Canis familiaris [Reaction:R-RNO-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - Rattus norvegicus [Reaction:R-MMU-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9633006] p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
precedingEvent	[Reaction:R-HSA-381087] Dimerization of PERK - Homo sapiens
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 [InstanceEdit:638652] Urano, F, 2010-04-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-381111
summation	[Summation:380990] The C-terminal domain of PERK (EIF2AK3) has kinase activity ...

Referrals

(hasEvent)	[Pathway:R-HSA-381042] PERK regulates gene expression
(precedingEvent)	[BlackBoxEvent:R-HSA-381128] Translation of ATF4

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