Reactome | ATF4 and CEBPB,CEBPG bind the ASNS gene

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ATF4 and CEBPB,CEBPG bind the ASNS gene Show undefined attributes

authored	[InstanceEdit:9635874] May, Bruce, 2019-02-09
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9635911] May, Bruce, 2019-02-10
dbId	9635915
displayName	ATF4 and CEBPB,CEBPG bind the ASNS gene
edited	[InstanceEdit:9635874] May, Bruce, 2019-02-09
eventOf	[Pathway:R-HSA-9633012] Response of EIF2AK4 (GCN2) to amino acid deficiency - Homo sapiens [Pathway:R-HSA-9648895] Response of EIF2AK1 (HRI) to heme deficiency - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1791118] Expression of ASNS (Asparagine Synthetase) - Homo sapiens
inferredFrom	[Reaction:R-MMU-9644310] Atf4 and Cebpg bind the Asns gene - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-5642307] ASNS gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-381016] ATF4 [nucleoplasm] [DefinedSet:R-HSA-9658331] CEBPB,CEBPG [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9635924] Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation [LiteratureReference:9658330] CCAAT/enhancer-binding protein-beta is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ATF4 and CEBPB,CEBPG bind the ASNS gene
output	[Complex:R-HSA-9635898] ATF4:CEBPB,CEBPG:ASNS gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-381128] Translation of ATF4 - Homo sapiens
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9661246] Bruhat, Alain, 2019-09-15 [InstanceEdit:9664254] Chen, Jane-Jane, 2019-10-22 [InstanceEdit:9668172] Staschke, Kirk A, 2019-11-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9635915
summation	[Summation:9635960] ATF4 and CEBPB or CEBPG bind a CEBP-ATF regulatory element (...

Referrals

(hasEvent)	[Pathway:R-HSA-9648895] Response of EIF2AK1 (HRI) to heme deficiency [Pathway:R-HSA-9633012] Response of EIF2AK4 (GCN2) to amino acid deficiency
(precedingEvent)	[BlackBoxEvent:R-HSA-1791118] Expression of ASNS (Asparagine Synthetase)
(inferredTo)	[Reaction:R-MMU-9644310] Atf4 and Cebpg bind the Asns gene