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Entries
PERK regulates gene expression
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authored
[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
compartment
[Compartment:70101] cytosol
[Compartment:17957] endoplasmic reticulum lumen
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:7660] nucleoplasm
created
[InstanceEdit:381159] May, B, 2008-11-19 16:17:44
dbId
381042
displayName
PERK regulates gene expression
edited
[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
eventOf
[Pathway:R-HSA-381119] Unfolded Protein Response (UPR) - Homo sapiens
figure
[Figure:387457] /figures/Kaufman2002-PERK.jpg
goBiologicalProcess
[GO_BiologicalProcess:5673196] PERK-mediated unfolded protein response
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-381086] Dissociation of PERK:BiP Heterodimer - Homo sapiens
[Reaction:R-HSA-381087] Dimerization of PERK - Homo sapiens
[Reaction:R-HSA-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - Homo sapiens
[BlackBoxEvent:R-HSA-381128] Translation of ATF4 - Homo sapiens
[Pathway:R-HSA-380994] ATF4 activates genes in response to endoplasmic reticulum stress - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:381103] The role for endoplasmic reticulum stress in diabetes mellitus
[LiteratureReference:381145] PERK in the life and death of the pancreatic beta-cell
[LiteratureReference:380997] The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes
[LiteratureReference:381027] Endoplasmic reticulum stress responses
modified
[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name
PERK regulates gene expression
orthologousEvent
[Pathway:R-CEL-381042] PERK regulates gene expression - Caenorhabditis elegans
[Pathway:R-DME-381042] PERK regulates gene expression - Drosophila melanogaster
[Pathway:R-GGA-381042] PERK regulates gene expression - Gallus gallus
[Pathway:R-XTR-381042] PERK regulates gene expression - Xenopus tropicalis
[Pathway:R-SSC-381042] PERK regulates gene expression - Sus scrofa
[Pathway:R-BTA-381042] PERK regulates gene expression - Bos taurus
[Pathway:R-CFA-381042] PERK regulates gene expression - Canis familiaris
[Pathway:R-RNO-381042] PERK regulates gene expression - Rattus norvegicus
[Pathway:R-MMU-381042] PERK regulates gene expression - Mus musculus
releaseDate
2009-06-24
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
[InstanceEdit:638652] Urano, F, 2010-04-30
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-381042
summation
[Summation:381073] PERK (EIF2AK3) is a single-pass transmembrane protein locate...
Referrals
(hasEvent)
[Pathway:R-HSA-381119] Unfolded Protein Response (UPR)
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