Reactome | PERK regulates gene expression

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PERK regulates gene expression Show undefined attributes

authored	[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
compartment	[Compartment:70101] cytosol [Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:381159] May, B, 2008-11-19 16:17:44
dbId	381042
displayName	PERK regulates gene expression
edited	[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
eventOf	[Pathway:R-HSA-381119] Unfolded Protein Response (UPR) - Homo sapiens
figure	[Figure:387457] /figures/Kaufman2002-PERK.jpg
goBiologicalProcess	[GO_BiologicalProcess:5673196] PERK-mediated unfolded protein response
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-381086] Dissociation of PERK:BiP Heterodimer - Homo sapiens [Reaction:R-HSA-381087] Dimerization of PERK - Homo sapiens [Reaction:R-HSA-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - Homo sapiens [BlackBoxEvent:R-HSA-381128] Translation of ATF4 - Homo sapiens [Pathway:R-HSA-380994] ATF4 activates genes in response to endoplasmic reticulum stress - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:381103] The role for endoplasmic reticulum stress in diabetes mellitus [LiteratureReference:381145] PERK in the life and death of the pancreatic beta-cell [LiteratureReference:380997] The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes [LiteratureReference:381027] Endoplasmic reticulum stress responses
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	PERK regulates gene expression
orthologousEvent	[Pathway:R-CEL-381042] PERK regulates gene expression - Caenorhabditis elegans [Pathway:R-DME-381042] PERK regulates gene expression - Drosophila melanogaster [Pathway:R-GGA-381042] PERK regulates gene expression - Gallus gallus [Pathway:R-XTR-381042] PERK regulates gene expression - Xenopus tropicalis [Pathway:R-SSC-381042] PERK regulates gene expression - Sus scrofa [Pathway:R-BTA-381042] PERK regulates gene expression - Bos taurus [Pathway:R-CFA-381042] PERK regulates gene expression - Canis familiaris [Pathway:R-RNO-381042] PERK regulates gene expression - Rattus norvegicus [Pathway:R-MMU-381042] PERK regulates gene expression - Mus musculus
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 [InstanceEdit:638652] Urano, F, 2010-04-30
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-381042
summation	[Summation:381073] PERK (EIF2AK3) is a single-pass transmembrane protein locate...

Referrals

(hasEvent)

[Pathway:R-HSA-381119] Unfolded Protein Response (UPR)

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