Reactome | Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein

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Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein Show undefined attributes

authored	[InstanceEdit:1655515] May, B, 2011-10-13
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1791110] May, B, 2011-10-21
dbId	1791107
displayName	Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein
edited	[InstanceEdit:1655515] May, B, 2011-10-13
eventOf	[Pathway:R-HSA-381183] ATF6 (ATF6-alpha) activates chaperone genes - Homo sapiens [Pathway:R-HSA-380994] ATF4 activates genes in response to endoplasmic reticulum stress - Homo sapiens
inferredFrom	[BlackBoxEvent:R-CGR-9635841] Expression of DDIT3 - Cricetulus griseus [BlackBoxEvent:R-RNO-9635847] Expression of Ddit3 - Rattus norvegicus
input	[EntityWithAccessionedSequence:R-HSA-5642256] DDIT3 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:381102] ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response [LiteratureReference:9644917] Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein
output	[EntityWithAccessionedSequence:R-HSA-381110] DDIT3 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-381026] ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus - Homo sapiens [BlackBoxEvent:R-HSA-381128] Translation of ATF4 - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-1791208] Positive gene expression regulation by 'NF-Y [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-1791221] Positive gene expression regulation by 'ATF6(1-380) [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-1791227] Positive gene expression regulation by 'ATF4 [nucleoplasm]'
regulationReference	[RegulationReference:9641193] Positive gene expression regulation by 'NF-Y [nucleoplasm]' ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response [RegulationReference:9642733] Positive gene expression regulation by 'ATF6(1-380) [nucleoplasm]' ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response [RegulationReference:9641581] Positive gene expression regulation by 'ATF4 [nucleoplasm]' Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 [InstanceEdit:638652] Urano, F, 2010-04-30
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1791107
summation	[Summation:1791175] The DDIT3 (CHOP) gene is transcribed to yield mRNA and the m...
updateTrackers	[UpdateTracker:9775825] Update Tracker - [BlackBoxEvent:1791107] Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein - v78:[modifyText] [UpdateTracker:9785906] Update Tracker - [BlackBoxEvent:1791107] Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein - v51:[addInput] [UpdateTracker:9777708] Update Tracker - [BlackBoxEvent:1791107] Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein - v69:[add_removeLiteratureReference, add_removeRegulator] [UpdateTracker:9778061] Update Tracker - [BlackBoxEvent:1791107] Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein - v68:[addLiteratureReference, add_removeRegulator, modifyText] [UpdateTracker:9777554] Update Tracker - [BlackBoxEvent:1791107] Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein - v70:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775825] Update Tracker - [BlackBoxEvent:1791107] Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein - v78:[modifyText] [UpdateTracker:9785906] Update Tracker - [BlackBoxEvent:1791107] Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein - v51:[addInput] [UpdateTracker:9777708] Update Tracker - [BlackBoxEvent:1791107] Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein - v69:[add_removeLiteratureReference, add_removeRegulator] [UpdateTracker:9778061] Update Tracker - [BlackBoxEvent:1791107] Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein - v68:[addLiteratureReference, add_removeRegulator, modifyText] [UpdateTracker:9777554] Update Tracker - [BlackBoxEvent:1791107] Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein - v70:[modifyText]
(hasEvent)	[Pathway:R-HSA-381183] ATF6 (ATF6-alpha) activates chaperone genes [Pathway:R-HSA-380994] ATF4 activates genes in response to endoplasmic reticulum stress
(inferredTo)	[BlackBoxEvent:R-RNO-9635847] Expression of Ddit3 [BlackBoxEvent:R-CGR-9635841] Expression of DDIT3

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