Translation of ATF4

Stable Identifier
R-HSA-381128
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Translation of ATF4
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ATF4 mRNA is translated to yield ATF4 protein, which then transits to the nucleus (Blais et al. 2004, Ross et al. 2018). The mRNA of ATF4 contains 2 upstream ORFs (uORFs) (Ross et al. 2018 and inferred from the mouse homolog). The second uORF overlaps the ORF encoding ATF4 and thus prevents translation of ATF4. When EIF2S1 (eIF2-alpha) is phosphorylated, translation initiation is decreased overall, translation of the uORFs is suppressed, and translation of the ORF encoding ATF4 is increased (Blais et al. 2004, Ross et al. 2018, and inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
15314157 Activating transcription factor 4 is translationally regulated by hypoxic stress

Blais, JD, Filipenko, V, Bi, M, Harding, HP, Ron, D, Koumenis, C, Wouters, BG, Bell, JC

Mol Cell Biol 2004
30551605 Eukaryotic Initiation Factor 5B (eIF5B) Cooperates with eIF1A and eIF5 to Facilitate uORF2-Mediated Repression of ATF4 Translation

Ross, JA, Bressler, KR, Thakor, N

Int J Mol Sci 2018
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Inferred From
Translation of Atf4 (Mus musculus)
Authored
May, B  (2009-06-02)
Reviewed
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Gillespie, ME  (2008-12-02)
Urano, F  (2010-04-30)
Bruhat, A  (2019-09-15)
Chen, JJ  (2019-10-22)
Staschke, KA  (2019-11-20)
Created
May, B  (2008-11-19)
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