Reactome | FLIP(S) and procaspase-8 form heterodimer

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FLIP(S) and procaspase-8 form heterodimer Show undefined attributes

authored	[InstanceEdit:3371406] Shamovsky, V, 2013-05-13
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:3465480] Shamovsky, V, 2013-05-17
dbId	3465429
displayName	FLIP(S) and procaspase-8 form heterodimer
edited	[InstanceEdit:3508822] Shamovsky, V, 2013-05-17
eventOf	[Pathway:R-HSA-5218900] CASP8 activity is inhibited - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:3446166] negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
input	[Complex:R-HSA-3465443] DISC:procaspase-8 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-3465357] FLIP(S) [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1267786] FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity [LiteratureReference:3465423] Association of TRAF2 with the short form of cellular FLICE-like inhibitory protein prevents TNFR1-mediated apoptosis [LiteratureReference:3465503] NF-kappaB signals induce the expression of c-FLIP [LiteratureReference:3465385] The role of c-FLIP in modulation of CD95-induced apoptosis
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	FLIP(S) and procaspase-8 form heterodimer
orthologousEvent	[Reaction:R-DME-3465429] FLIP(S) and procaspase-8 form heterodimer - Drosophila melanogaster [Reaction:R-GGA-3465429] FLIP(S) and procaspase-8 form heterodimer - Gallus gallus [Reaction:R-DRE-3465429] FLIP(S) and procaspase-8 form heterodimer - Danio rerio [Reaction:R-SSC-3465429] FLIP(S) and procaspase-8 form heterodimer - Sus scrofa [Reaction:R-BTA-3465429] FLIP(S) and procaspase-8 form heterodimer - Bos taurus [Reaction:R-CFA-3465429] FLIP(S) and procaspase-8 form heterodimer - Canis familiaris [Reaction:R-RNO-3465429] FLIP(S) and procaspase-8 form heterodimer - Rattus norvegicus [Reaction:R-MMU-3465429] FLIP(S) and procaspase-8 form heterodimer - Mus musculus
output	[Complex:R-HSA-3465352] DISC:procaspase-8:FLIP(S) [plasma membrane]
precedingEvent	[Reaction:R-HSA-83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - Homo sapiens [Reaction:R-HSA-75240] TRADD:TRAF2:RIP1:FADD binds pro-caspase 8 - Homo sapiens [Reaction:R-HSA-75146] TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22 [InstanceEdit:5675023] Chan, Francis Ka-Ming, 2015-02-15 [InstanceEdit:9698846] Murphy, James M, 2020-08-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3465429
summation	[Summation:3465395] The short form of cellular FLIP (FLIP(S) or c-FLIPS) has two...
updateTrackers	[UpdateTracker:9776755] Update Tracker - [Reaction:3465429] FLIP(S) and procaspase-8 form heterodimer - v74:[modifyText] [UpdateTracker:9785169] Update Tracker - [Reaction:3465429] FLIP(S) and procaspase-8 form heterodimer - v52:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776755] Update Tracker - [Reaction:3465429] FLIP(S) and procaspase-8 form heterodimer - v74:[modifyText] [UpdateTracker:9785169] Update Tracker - [Reaction:3465429] FLIP(S) and procaspase-8 form heterodimer - v52:[modifyText]
(hasEvent)	[Pathway:R-HSA-5218900] CASP8 activity is inhibited

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