Reactome | CASP8 activity is inhibited

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CASP8 activity is inhibited Show undefined attributes

authored	[InstanceEdit:5218858] Shamovsky, V, 2013-12-20
created	[InstanceEdit:5218889] Shamovsky, V, 2013-12-20
crossReference	[DatabaseIdentifier:12819567] BioModels Database:BIOMD0000000525 [DatabaseIdentifier:12819569] BioModels Database:BIOMD0000000523 [DatabaseIdentifier:12819571] BioModels Database:BIOMD0000000524 [DatabaseIdentifier:12819573] BioModels Database:BIOMD0000000243 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220 [DatabaseIdentifier:12819459] BioModels Database:BIOMD0000000407 [DatabaseIdentifier:12819695] BioModels Database:BIOMD0000000661 [DatabaseIdentifier:12819575] BioModels Database:BIOMD0000000526 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	5218900
displayName	CASP8 activity is inhibited
edited	[InstanceEdit:5673737] Shamovsky, V, 2015-02-09
eventOf	[Pathway:R-HSA-5675482] Regulation of necroptotic cell death - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:422917] negative regulation of endopeptidase activity
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-3465429] FLIP(S) and procaspase-8 form heterodimer - Homo sapiens [Reaction:R-HSA-5675456] FLIP(L) and procaspase-8 form heterodimer - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-09-14
literatureReference	[LiteratureReference:2672187] Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors [LiteratureReference:5357858] Differential effects of caspase inhibitors on TNF-induced necroptosis [LiteratureReference:2584548] Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA [LiteratureReference:2562551] cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	CASP8 activity is inhibited
orthologousEvent	[Pathway:R-DME-5218900] CASP8 activity is inhibited - Drosophila melanogaster [Pathway:R-GGA-5218900] CASP8 activity is inhibited - Gallus gallus [Pathway:R-DRE-5218900] CASP8 activity is inhibited - Danio rerio [Pathway:R-SSC-5218900] CASP8 activity is inhibited - Sus scrofa [Pathway:R-BTA-5218900] CASP8 activity is inhibited - Bos taurus [Pathway:R-CFA-5218900] CASP8 activity is inhibited - Canis familiaris [Pathway:R-RNO-5218900] CASP8 activity is inhibited - Rattus norvegicus [Pathway:R-MMU-5218900] CASP8 activity is inhibited - Mus musculus
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30 [InstanceEdit:5675023] Chan, Francis Ka-Ming, 2015-02-15 [InstanceEdit:9698846] Murphy, James M, 2020-08-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5218900
summation	[Summation:5357818] Cell death triggered by extrinsic stimuli via death receptor...
updateTrackers	[UpdateTracker:9776820] Update Tracker - [Pathway:5218900] CASP8 activity is inhibited - v74:[modifyText, updateContainedRLE] [UpdateTracker:9784572] Update Tracker - [Pathway:5218900] CASP8 activity is inhibited - v53:[updateContainedRLE] [UpdateTracker:9847006] Update Tracker - [Pathway:5218900] CASP8 activity is inhibited - v82:[removeHasEvent]

Referrals

(updatedInstance)	[UpdateTracker:9776820] Update Tracker - [Pathway:5218900] CASP8 activity is inhibited - v74:[modifyText, updateContainedRLE] [UpdateTracker:9784572] Update Tracker - [Pathway:5218900] CASP8 activity is inhibited - v53:[updateContainedRLE] [UpdateTracker:9847006] Update Tracker - [Pathway:5218900] CASP8 activity is inhibited - v82:[removeHasEvent]
(hasEvent)	[Pathway:R-HSA-5675482] Regulation of necroptotic cell death

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