FLIP(S) and procaspase-8 form heterodimer

Stable Identifier
R-HSA-3465429
Type
Reaction
Species
Homo sapiens
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The short form of cellular FLIP (FLIP(S) or c-FLIPS) has two death effector domains DEDs, which can bind to FADD and caspase-8 (CASP8). FLIP(S) protects the cells from apoptosis by inhibiting the processing of caspase-8 at the receptor level (Scaffidi C et al. 1999; Micheau O et al 2001).

FLIP(S) is a short-lived protein which is sensitive to ubiquitination and proteasomal degradation (Poukkula M et al. 2005). Protein kinase C (PKC)- mediated phosphorylation of FLIP(S) at Ser193 was shown to prolongs the half-life of FLIP(S) by inhibiting its polyubiquitination (Kaunisto A et al. 2009).

Literature References
PubMed ID Title Journal Year
9880531 The role of c-FLIP in modulation of CD95-induced apoptosis

Krammer, PH, Peter, ME, Schmitz, I, Scaffidi, C

J. Biol. Chem. 1999
11463813 NF-kappaB signals induce the expression of c-FLIP

Gaide, O, Micheau, O, Tschopp, J, Lens, S, Alevizopoulos, K

Mol. Cell. Biol. 2001
18190721 Association of TRAF2 with the short form of cellular FLICE-like inhibitory protein prevents TNFR1-mediated apoptosis

Kim, YY, Oh, B, Park, C, Kim, DJ

J Mol Signal 2008
21235526 FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

Drag, M, Van Raam, BJ, Oberst, A, Green, DR, Riedl, SJ, Salvesen, GS, Pop, C

Biochem J 2011
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