Reactome | The short form of cellular FLIP (FLIP(S) or c-FLIPS) has two...

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created	[InstanceEdit:3465480] Shamovsky, V, 2013-05-17
dbId	3465395
displayName	The short form of cellular FLIP (FLIP(S) or c-FLIPS) has two...
literatureReference	[LiteratureReference:3465385] The role of c-FLIP in modulation of CD95-induced apoptosis [LiteratureReference:3465368] Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail [LiteratureReference:3465330] PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability [LiteratureReference:3465503] NF-kappaB signals induce the expression of c-FLIP
modified	[InstanceEdit:9696115] Shamovsky, Veronica, 2020-07-17
schemaClass	Summation
text	The short form of cellular FLIP (FLIP(S) or c-FLIPS) has two death effector domains DEDs, which can bind to FADD and caspase-8 (CASP8). FLIP(S) protects the cells from apoptosis by inhibiting the processing of caspase-8 at the receptor level (Scaffidi C et al. 1999; Micheau O et al 2001). FLIP(S) is a short-lived protein which is sensitive to ubiquitination and proteasomal degradation (Poukkula M et al. 2005). Protein kinase C (PKC)- mediated phosphorylation of FLIP(S) at Ser193 was shown to prolongs the half-life of FLIP(S) by inhibiting its polyubiquitination (Kaunisto A et al. 2009).

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