Reactome | FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8

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FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 Show undefined attributes

authored	[InstanceEdit:140952] Gillespie, ME, 2004-08-24 21:33:15
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:110071] Tschopp, J�rg, 2004-01-28
dbId	83586
displayName	FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
eventOf	[Pathway:R-HSA-75157] FasL/ CD95L signaling - Homo sapiens
figure	[Figure:141228] /figures/FasL_Fas_FADD_ProCaspase8.jpg
followingEvent	[Reaction:R-HSA-3465459] FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling - Homo sapiens [Reaction:R-HSA-5675456] FLIP(L) and procaspase-8 form heterodimer - Homo sapiens [Reaction:R-HSA-3465429] FLIP(S) and procaspase-8 form heterodimer - Homo sapiens [Reaction:R-HSA-73945] FAS-mediated dimerization of procaspase-8 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-57031] CASP8(1-479) [cytosol] [Complex:R-HSA-43124] FASL:FAS Receptor Trimer:FADD [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:140941] Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
orthologousEvent	[Reaction:R-GGA-83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - Gallus gallus [Reaction:R-SSC-83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - Sus scrofa [Reaction:R-BTA-83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - Bos taurus [Reaction:R-RNO-83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - Rattus norvegicus [Reaction:R-MMU-83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - Mus musculus
output	[Complex:R-HSA-75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane]
precedingEvent	[Reaction:R-HSA-83650] FasL:Fas binds FADD - Homo sapiens
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-83586
summation	[Summation:178764] Caspase-8 precursor (Pro-Caspase-8, also known as MACH) bind...
updateTrackers	[UpdateTracker:9788296] Update Tracker - [Reaction:83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - v43:[modifyText] [UpdateTracker:9787964] Update Tracker - [Reaction:83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - v44:[addRegulator] [UpdateTracker:9786502] Update Tracker - [Reaction:83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - v49:[removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9788296] Update Tracker - [Reaction:83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - v43:[modifyText] [UpdateTracker:9787964] Update Tracker - [Reaction:83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - v44:[addRegulator] [UpdateTracker:9786502] Update Tracker - [Reaction:83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - v49:[removeRegulator]
(precedingEvent)	[Reaction:R-HSA-3465459] FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling [Reaction:R-HSA-5675456] FLIP(L) and procaspase-8 form heterodimer [Reaction:R-HSA-3465429] FLIP(S) and procaspase-8 form heterodimer [Reaction:R-HSA-73945] FAS-mediated dimerization of procaspase-8
(hasEvent)	[Pathway:R-HSA-75157] FasL/ CD95L signaling

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