Reactome | FLIP(S) and procaspase-8 form heterodimer

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FLIP(S) and procaspase-8 form heterodimer Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10873967
displayName	FLIP(S) and procaspase-8 form heterodimer
eventOf	[Pathway:R-DME-5218900] CASP8 activity is inhibited - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:3446166] negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
inferredFrom	[Reaction:R-HSA-3465429] FLIP(S) and procaspase-8 form heterodimer - Homo sapiens
input	[DefinedSet:R-DME-3465357-6] Homologues of FLIP(S) [cytosol] [Complex:R-DME-140976] TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	FLIP(S) and procaspase-8 form heterodimer
output	[Complex:R-DME-3465352] DISC:procaspase-8:FLIP(S) [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-3465429
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5218900] CASP8 activity is inhibited
(inferredTo)	[Reaction:R-HSA-3465429] FLIP(S) and procaspase-8 form heterodimer

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