Reactome | TRADD:TRAF2:RIP1:FADD binds pro-caspase 8

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TRADD:TRAF2:RIP1:FADD binds pro-caspase 8 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:110071] Tschopp, J�rg, 2004-01-28
dbId	75240
displayName	TRADD:TRAF2:RIP1:FADD binds pro-caspase 8
edited	[InstanceEdit:5675041] Shamovsky, V, 2015-02-15
eventOf	[Pathway:R-HSA-5357786] TNFR1-induced proapoptotic signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-141159] TNF-mediated dimerization of procaspase-8 - Homo sapiens [Reaction:R-HSA-5675456] FLIP(L) and procaspase-8 form heterodimer - Homo sapiens [Reaction:R-HSA-3465429] FLIP(S) and procaspase-8 form heterodimer - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-57031] CASP8(1-479) [cytosol] [Complex:R-HSA-140977] TRADD:TRAF2:RIPK1:FADD [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:140979] Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
maxDepth	1
modified	[InstanceEdit:9920910] Shamovsky, Veronica, 2024-09-04
name	TRADD:TRAF2:RIP1:FADD binds pro-caspase 8
output	[Complex:R-HSA-140976] TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol]
precedingEvent	[Reaction:R-HSA-140978] TRADD:TRAF2:RIP1 binds FADD - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-5692563] Negative regulation by 'CASP8(1-479):UL36 [cytosol]' [NegativeRegulation:9828541] Negative regulation by 'OPTN:CASP8 [cytosol]'
regulationReference	[RegulationReference:9641752] Negative regulation by 'CASP8(1-479):UL36 [cytosol]' A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation [RegulationReference:9828539] Negative regulation by 'OPTN:CASP8 [cytosol]' Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis
relatedSpecies	[Species:2671791] Human cytomegalovirus
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22 [InstanceEdit:6792551] Wajant, Harald, 2015-08-25 [InstanceEdit:9828415] Muniti?, Ivana, 2023-02-14 [InstanceEdit:9830259] Franjki?, Toni, 2023-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-75240
summation	[Summation:179240] Tumor necrosis factor ? (TNF-?)-induced apoptosis is regulat...
updateTrackers	[UpdateTracker:9788121] Update Tracker - [Reaction:75240] TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 - v43:[modifyText] [UpdateTracker:9784359] Update Tracker - [Reaction:75240] TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 - v54:[addRegulator] [UpdateTracker:9846759] Update Tracker - [Reaction:75240] TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 - v84:[addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788121] Update Tracker - [Reaction:75240] TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 - v43:[modifyText] [UpdateTracker:9784359] Update Tracker - [Reaction:75240] TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 - v54:[addRegulator] [UpdateTracker:9846759] Update Tracker - [Reaction:75240] TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 - v84:[addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-5357786] TNFR1-induced proapoptotic signaling
(precedingEvent)	[Reaction:R-HSA-5675456] FLIP(L) and procaspase-8 form heterodimer [Reaction:R-HSA-3465429] FLIP(S) and procaspase-8 form heterodimer [Reaction:R-HSA-141159] TNF-mediated dimerization of procaspase-8

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