Reactome | Beta-catenin displaces TLE:HDAC1 from TCF/LEF

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Beta-catenin displaces TLE:HDAC1 from TCF/LEF Show undefined attributes

authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
category	dissociation
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3299568] Rothfels, K, 2013-04-18
dbId	3299569
displayName	Beta-catenin displaces TLE:HDAC1 from TCF/LEF
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-201722] Formation of the beta-catenin:TCF transactivating complex - Homo sapiens
followingEvent	[Reaction:R-HSA-9824236] MSGN1 and LEF1:CTNNB1 bind the DLL1 gene in presomitic mesoderm - Homo sapiens [Reaction:R-HSA-9909632] CTNNB1 binding to CD274 gene - Homo sapiens [Reaction:R-HSA-3322424] Beta-catenin recruits CDC73 and LEO1 - Homo sapiens [Reaction:R-HSA-3322427] Beta-catenin recruits CBP/p300 - Homo sapiens [Reaction:R-HSA-3451153] Beta-catenin recruits TRRAP/KAT5 HAT components - Homo sapiens [Reaction:R-HSA-201712] Beta-catenin:TCF associates with BCL9 and PYGO - Homo sapiens [Reaction:R-HSA-8944362] TCF/LEF:CTNNB1 bind canonical WNT target promoters - Homo sapiens [Reaction:R-HSA-3322431] XIAP binds TLE - Homo sapiens [Reaction:R-HSA-5665608] TCF:Beta-catenin binds SOX proteins - Homo sapiens [Reaction:R-HSA-3322422] Beta-catenin recruits SMARCA4 - Homo sapiens [Reaction:R-HSA-9793887] TBX6 and LEF1:CTNNB1 bind the DLL1 gene - Homo sapiens [Reaction:R-HSA-9793382] TBX6 and LEF1:CTNNB1 bind the MSGN1 gene - Homo sapiens [BlackBoxEvent:R-HSA-9796300] Expression of NOTO in axial mesoderm - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3451168] CTNNB1 [nucleoplasm] [Complex:R-HSA-3299555] TCF/LEF:TLE:HDAC1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208367] Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation [LiteratureReference:3299525] TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling [LiteratureReference:3299509] A role for Groucho tetramerization in transcriptional repression [LiteratureReference:3299519] Groucho oligomerization is required for repression in vivo [LiteratureReference:3299514] Crystal structure of a beta-catenin/Tcf complex [LiteratureReference:201944] Structure of a human Tcf4-beta-catenin complex [LiteratureReference:3299516] Functional interaction of beta-catenin with the transcription factor LEF-1 [LiteratureReference:201927] Identification of Tcf4 residues involved in high-affinity beta-catenin binding [LiteratureReference:3299530] Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse [LiteratureReference:3299531] XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos [LiteratureReference:3299517] Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression [LiteratureReference:3299522] Groucho/TLE family proteins and transcriptional repression [LiteratureReference:3299528] Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors [LiteratureReference:3299508] A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development [LiteratureReference:3299523] Products of the grg (Groucho-related gene) family can dimerize through the amino-terminal Q domain [LiteratureReference:3305814] Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Beta-catenin displaces TLE:HDAC1 from TCF/LEF
negativePrecedingEvent	[NegativePrecedingEvent:9965519] Futile Cycle: beta-catenin is replaced by repression complexes at the promoter
orthologousEvent	[Reaction:R-MMU-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Mus musculus [Reaction:R-RNO-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Rattus norvegicus [Reaction:R-CFA-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Canis familiaris [Reaction:R-BTA-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Bos taurus [Reaction:R-SSC-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Sus scrofa [Reaction:R-DRE-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Danio rerio [Reaction:R-XTR-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Xenopus tropicalis [Reaction:R-GGA-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Gallus gallus [Reaction:R-DME-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Drosophila melanogaster [Reaction:R-CEL-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Caenorhabditis elegans
output	[EntityWithAccessionedSequence:R-HSA-205021] HDAC1 [nucleoplasm] [Complex:R-HSA-3299548] TCF/LEF:CTNNB1 [nucleoplasm] [DefinedSet:R-HSA-3299565] TLE tetramer [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-201669] Beta-catenin translocates to the nucleus - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3299569
summation	[Summation:3299537] TCF7 (TCF1), LEF1, TCF7L1 (TCF3) and TCF7L2 (TCF4) are HMG b...
updateTrackers	[UpdateTracker:9971922] Update Tracker - [Reaction:3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - v95:[modifyText] [UpdateTracker:9782268] Update Tracker - [Reaction:3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - v59:[modifyText]

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9796300] Expression of NOTO in axial mesoderm [Reaction:R-HSA-9824236] MSGN1 and LEF1:CTNNB1 bind the DLL1 gene in presomitic mesoderm [Reaction:R-HSA-9793887] TBX6 and LEF1:CTNNB1 bind the DLL1 gene [Reaction:R-HSA-9793382] TBX6 and LEF1:CTNNB1 bind the MSGN1 gene [Reaction:R-HSA-9909632] CTNNB1 binding to CD274 gene [Reaction:R-HSA-3322424] Beta-catenin recruits CDC73 and LEO1 [Reaction:R-HSA-3322427] Beta-catenin recruits CBP/p300 [Reaction:R-HSA-3451153] Beta-catenin recruits TRRAP/KAT5 HAT components [Reaction:R-HSA-201712] Beta-catenin:TCF associates with BCL9 and PYGO [Reaction:R-HSA-8944362] TCF/LEF:CTNNB1 bind canonical WNT target promoters [Reaction:R-HSA-3322431] XIAP binds TLE [Reaction:R-HSA-5665608] TCF:Beta-catenin binds SOX proteins [Reaction:R-HSA-3322422] Beta-catenin recruits SMARCA4
(hasEvent)	[Pathway:R-HSA-201722] Formation of the beta-catenin:TCF transactivating complex
(updatedInstance)	[UpdateTracker:9971922] Update Tracker - [Reaction:3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - v95:[modifyText] [UpdateTracker:9782268] Update Tracker - [Reaction:3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - v59:[modifyText]

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