Reactome | Formation of the beta-catenin:TCF transactivating complex

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Formation of the beta-catenin:TCF transactivating complex Show undefined attributes

authored	[InstanceEdit:4415000] Rothfels, K, 2013-08-23
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:201703] Matthews, L, 2007-09-10 21:56:08
dbId	201722
displayName	Formation of the beta-catenin:TCF transactivating complex
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02 [InstanceEdit:201675] Matthews, L, 2007-09-04 11:49:29
eventOf	[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:8854802] beta-catenin-TCF complex assembly
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-HSA-4411364] Binding of TCF/LEF:CTNNB1 to target gene promoters - Homo sapiens [Reaction:R-HSA-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Homo sapiens [Reaction:R-HSA-201712] Beta-catenin:TCF associates with BCL9 and PYGO - Homo sapiens [Reaction:R-HSA-3322427] Beta-catenin recruits CBP/p300 - Homo sapiens [Reaction:R-HSA-3322424] Beta-catenin recruits CDC73 and LEO1 - Homo sapiens [Reaction:R-HSA-3322422] Beta-catenin recruits SMARCA4 - Homo sapiens [Reaction:R-HSA-3364014] Recruitment of SET1 methyltransferase complex - Homo sapiens [Reaction:R-HSA-3364026] SET1 complex trimethylates H3K4 at the MYC gene - Homo sapiens [Reaction:R-HSA-3451153] Beta-catenin recruits TRRAP/KAT5 HAT components - Homo sapiens [Reaction:R-HSA-3451147] KAT5 HAT complex acetylates TCF4 gene at histone H4 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3451139] Beta-catenin hits chromatin: regulation of Wnt target gene activation [LiteratureReference:3305839] The many faces and functions of ?-catenin [LiteratureReference:3451156] Wnt signaling: is the party in the nucleus? [LiteratureReference:3299514] Crystal structure of a beta-catenin/Tcf complex [LiteratureReference:201944] Structure of a human Tcf4-beta-catenin complex [LiteratureReference:5228655] Crystal structure of a full-length beta-catenin [LiteratureReference:3299525] TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling [LiteratureReference:3299522] Groucho/TLE family proteins and transcriptional repression [LiteratureReference:1458900] Wnt/beta-catenin signaling: components, mechanisms, and diseases [LiteratureReference:5323455] Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification [LiteratureReference:5323450] Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Formation of the beta-catenin:TCF transactivating complex
orthologousEvent	[Pathway:R-CEL-201722] Formation of the beta-catenin:TCF transactivating complex - Caenorhabditis elegans [Pathway:R-DME-201722] Formation of the beta-catenin:TCF transactivating complex - Drosophila melanogaster [Pathway:R-GGA-201722] Formation of the beta-catenin:TCF transactivating complex - Gallus gallus [Pathway:R-DRE-201722] Formation of the beta-catenin:TCF transactivating complex - Danio rerio [Pathway:R-SSC-201722] Formation of the beta-catenin:TCF transactivating complex - Sus scrofa [Pathway:R-BTA-201722] Formation of the beta-catenin:TCF transactivating complex - Bos taurus [Pathway:R-CFA-201722] Formation of the beta-catenin:TCF transactivating complex - Canis familiaris [Pathway:R-RNO-201722] Formation of the beta-catenin:TCF transactivating complex - Rattus norvegicus [Pathway:R-MMU-201722] Formation of the beta-catenin:TCF transactivating complex - Mus musculus
precedingEvent	[BlackBoxEvent:R-HSA-201669] Beta-catenin translocates to the nucleus - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-201722
summation	[Summation:3451158] Once in the nucleus, beta-catenin is recruited to WNT target...

Referrals

(hasEvent)

[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT

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