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Schema
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Entries
Formation of the beta-catenin:TCF transactivating complex
Show undefined attributes
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authored
[InstanceEdit:4415000] Rothfels, K, 2013-08-23
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:201703] Matthews, L, 2007-09-10 21:56:08
dbId
201722
displayName
Formation of the beta-catenin:TCF transactivating complex
edited
[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
[InstanceEdit:201675] Matthews, L, 2007-09-04 11:49:29
eventOf
[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:8854802] beta-catenin-TCF complex assembly
hasDiagram
false
hasEHLD
false
hasEvent
[Pathway:R-HSA-4411364] Binding of TCF/LEF:CTNNB1 to target gene promoters - Homo sapiens
[Reaction:R-HSA-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Homo sapiens
[Reaction:R-HSA-201712] Beta-catenin:TCF associates with BCL9 and PYGO - Homo sapiens
[Reaction:R-HSA-3322427] Beta-catenin recruits CBP/p300 - Homo sapiens
[Reaction:R-HSA-3322424] Beta-catenin recruits CDC73 and LEO1 - Homo sapiens
[Reaction:R-HSA-3322422] Beta-catenin recruits SMARCA4 - Homo sapiens
[Reaction:R-HSA-3364014] Recruitment of MLL2 methyltransferase complex - Homo sapiens
[Reaction:R-HSA-3364026] MLL2 complex trimethylates H3K4 at the MYC gene - Homo sapiens
[Reaction:R-HSA-3451153] Beta-catenin recruits TRRAP/KAT5 HAT components - Homo sapiens
[Reaction:R-HSA-3451147] KAT5 HAT complex acetylates TCF4 gene at histone H4 - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2018-03-26
literatureReference
[LiteratureReference:3451139] Beta-catenin hits chromatin: regulation of Wnt target gene activation
[LiteratureReference:3305839] The many faces and functions of ?-catenin
[LiteratureReference:3451156] Wnt signaling: is the party in the nucleus?
[LiteratureReference:3299514] Crystal structure of a beta-catenin/Tcf complex
[LiteratureReference:201944] Structure of a human Tcf4-beta-catenin complex
[LiteratureReference:5228655] Crystal structure of a full-length beta-catenin
[LiteratureReference:3299525] TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling
[LiteratureReference:3299522] Groucho/TLE family proteins and transcriptional repression
[LiteratureReference:1458900] Wnt/beta-catenin signaling: components, mechanisms, and diseases
[LiteratureReference:5323455] Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification
[LiteratureReference:5323450] Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2
maxDepth
3
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
Formation of the beta-catenin:TCF transactivating complex
orthologousEvent
[Pathway:R-MMU-201722] Formation of the beta-catenin:TCF transactivating complex - Mus musculus
[Pathway:R-RNO-201722] Formation of the beta-catenin:TCF transactivating complex - Rattus norvegicus
[Pathway:R-CFA-201722] Formation of the beta-catenin:TCF transactivating complex - Canis familiaris
[Pathway:R-BTA-201722] Formation of the beta-catenin:TCF transactivating complex - Bos taurus
[Pathway:R-SSC-201722] Formation of the beta-catenin:TCF transactivating complex - Sus scrofa
[Pathway:R-DRE-201722] Formation of the beta-catenin:TCF transactivating complex - Danio rerio
[Pathway:R-XTR-201722] Formation of the beta-catenin:TCF transactivating complex - Xenopus tropicalis
[Pathway:R-GGA-201722] Formation of the beta-catenin:TCF transactivating complex - Gallus gallus
[Pathway:R-DME-201722] Formation of the beta-catenin:TCF transactivating complex - Drosophila melanogaster
[Pathway:R-CEL-201722] Formation of the beta-catenin:TCF transactivating complex - Caenorhabditis elegans
precedingEvent
[BlackBoxEvent:R-HSA-201669] Beta-catenin translocates to the nucleus - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2014-03-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
[InstanceEdit:5323527] van Amerongen, R, 2014-02-14
[InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-201722
summation
[Summation:3451158] Once in the nucleus, beta-catenin is recruited to WNT target...
updateTrackers
[UpdateTracker:9782615] Update Tracker - [Pathway:201722] Formation of the beta-catenin:TCF transactivating complex - v59:[updateContainedRLE]
[UpdateTracker:9780131] Update Tracker - [Pathway:201722] Formation of the beta-catenin:TCF transactivating complex - v64:[updateIndirectRLE]
[UpdateTracker:9781843] Update Tracker - [Pathway:201722] Formation of the beta-catenin:TCF transactivating complex - v60:[updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT
(updatedInstance)
[UpdateTracker:9782615] Update Tracker - [Pathway:201722] Formation of the beta-catenin:TCF transactivating complex - v59:[updateContainedRLE]
[UpdateTracker:9780131] Update Tracker - [Pathway:201722] Formation of the beta-catenin:TCF transactivating complex - v64:[updateIndirectRLE]
[UpdateTracker:9781843] Update Tracker - [Pathway:201722] Formation of the beta-catenin:TCF transactivating complex - v60:[updateIndirectRLE]
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