Reactome | Beta-catenin:TCF associates with BCL9 and PYGO

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Beta-catenin:TCF associates with BCL9 and PYGO Show undefined attributes

authored	[InstanceEdit:4415000] Rothfels, K, 2013-08-23
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:201703] Matthews, L, 2007-09-10 21:56:08
dbId	201712
displayName	Beta-catenin:TCF associates with BCL9 and PYGO
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-201722] Formation of the beta-catenin:TCF transactivating complex - Homo sapiens
followingEvent	[Reaction:R-HSA-3364014] Recruitment of MLL2 methyltransferase complex - Homo sapiens
input	[DefinedSet:R-HSA-3305844] BCL9 [nucleoplasm] [DefinedSet:R-HSA-3322379] PYGO [nucleoplasm] [Complex:R-HSA-3299548] TCF/LEF:CTNNB1 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208112] Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex [LiteratureReference:3305822] Crystal structure of a beta-catenin/BCL9/Tcf4 complex [LiteratureReference:3305750] Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21 [LiteratureReference:3305839] The many faces and functions of ?-catenin [LiteratureReference:3305789] Pygopus and the Wnt signaling pathway: a diverse set of connections [LiteratureReference:3305731] pygopus Encodes a nuclear protein essential for wingless/Wnt signaling [LiteratureReference:3305798] A new nuclear component of the Wnt signalling pathway [LiteratureReference:3305760] Probing transcription-specific outputs of ?-catenin in vivo [LiteratureReference:3305777] Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation [LiteratureReference:208361] Identification and in vivo role of the Armadillo-Legless interaction [LiteratureReference:3305793] Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin [LiteratureReference:208104] Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins [LiteratureReference:3305733] pygopus 2 has a crucial, Wnt pathway-independent function in lens induction [LiteratureReference:3305767] Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development [LiteratureReference:3305838] Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2 [LiteratureReference:3305816] Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin [LiteratureReference:3305830] Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex [LiteratureReference:3305788] The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3 [LiteratureReference:3305795] Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells [LiteratureReference:3322328] The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Beta-catenin:TCF associates with BCL9 and PYGO
negativePrecedingEvent	[NegativePrecedingEvent:9965525] Futile Cycle: APC promotes disassembly of beta-catenin transactivation complex
orthologousEvent	[Reaction:R-GGA-201712] Beta-catenin:TCF associates with BCL9 and PYGO - Gallus gallus [Reaction:R-DRE-201712] Beta-catenin:TCF associates with BCL9 and PYGO - Danio rerio [Reaction:R-SSC-201712] Beta-catenin:TCF associates with BCL9 and PYGO - Sus scrofa [Reaction:R-BTA-201712] Beta-catenin:TCF associates with BCL9 and PYGO - Bos taurus [Reaction:R-CFA-201712] Beta-catenin:TCF associates with BCL9 and PYGO - Canis familiaris [Reaction:R-RNO-201712] Beta-catenin:TCF associates with BCL9 and PYGO - Rattus norvegicus [Reaction:R-MMU-201712] Beta-catenin:TCF associates with BCL9 and PYGO - Mus musculus
output	[Complex:R-HSA-201917] TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm]
precedingEvent	[Reaction:R-HSA-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-201712
summation	[Summation:3305848] Once tethered at WNT promoters, beta-catenin is a scaffold f...

Referrals

(hasEvent)	[Pathway:R-HSA-201722] Formation of the beta-catenin:TCF transactivating complex
(precedingEvent)	[Reaction:R-HSA-3364014] Recruitment of MLL2 methyltransferase complex

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