Reactome | TBX6 and LEF1:CTNNB1 bind the DLL1 gene

Schema > Reaction > Entries

authored	[InstanceEdit:9793929] May, Bruce, 2022-06-19
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9793807] May, Bruce, 2022-06-24
dbId	9793887
displayName	TBX6 and LEF1:CTNNB1 bind the DLL1 gene
edited	[InstanceEdit:9793929] May, Bruce, 2022-06-19
eventOf	[Pathway:R-HSA-9793380] Formation of paraxial mesoderm - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9793921] Expression of DLL1 in paraxial mesoderm - Homo sapiens
inferredFrom	[Reaction:R-MMU-9793864] Tbx6 and Lef1:Ctnnb1 bind the Dll1 gene - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-9023392] DLL1 gene [nucleoplasm] [Complex:R-HSA-9735197] LEF1:CTNNB1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9793377] TBX6 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TBX6 and LEF1:CTNNB1 bind the DLL1 gene
output	[Complex:R-HSA-9793846] LEF1:CTNNB1:TBX6:DLL1 gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9793383] Expression of TBX6 in paraxial mesoderm - Homo sapiens [Reaction:R-HSA-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Homo sapiens
releaseDate	2022-12-07
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9820530] Yamaguchi, Terry P, 2022-11-09 [InstanceEdit:9820524] Chalamalasetty, Ravindra B, 2022-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9793887
summation	[Summation:9793858] LEF1 and CTNNB1 (beta-catenin) activated by WNT signaling bi...

(hasEvent)	[Pathway:R-HSA-9793380] Formation of paraxial mesoderm
(precedingEvent)	[BlackBoxEvent:R-HSA-9793921] Expression of DLL1 in paraxial mesoderm
(inferredTo)	[Reaction:R-MMU-9793864] Tbx6 and Lef1:Ctnnb1 bind the Dll1 gene

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