Reactome | TCF/LEF:CTNNB1 [nucleoplasm]

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TCF/LEF:CTNNB1 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-3322393] TCF/LEF:CTNNB1:PAF1-like complex [nucleoplasm] - Homo sapiens [Complex:R-HSA-3322396] TCF/LEF:CTNNB1:CBP/p300 [nucleoplasm] - Homo sapiens [Complex:R-HSA-3322391] TCF/LEF:CTNNB1:SMARCA4:TERT [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-3322424] Beta-catenin recruits CDC73 and LEO1 - Homo sapiens [Reaction:R-HSA-3322427] Beta-catenin recruits CBP/p300 - Homo sapiens [Reaction:R-HSA-3451153] Beta-catenin recruits TRRAP/KAT5 HAT components - Homo sapiens [Reaction:R-HSA-3322422] Beta-catenin recruits SMARCA4 - Homo sapiens [Reaction:R-HSA-5665608] TCF:Beta-catenin binds SOX proteins - Homo sapiens [Reaction:R-HSA-8944362] TCF/LEF:CTNNB1 bind canonical WNT target promoters - Homo sapiens [Reaction:R-HSA-201712] Beta-catenin:TCF associates with BCL9 and PYGO - Homo sapiens
created	[InstanceEdit:3299547] Rothfels, K, 2013-04-18
dbId	3299548
displayName	TCF/LEF:CTNNB1 [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-3451168] CTNNB1 [nucleoplasm] [CandidateSet:R-HSA-3299546] TCF/LEF [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-3299548] TCF/LEF:CTNNB1 [nucleoplasm] - Mus musculus [Complex:R-RNO-3299548] TCF/LEF:CTNNB1 [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-3299548] TCF/LEF:CTNNB1 [nucleoplasm] - Canis familiaris [Complex:R-BTA-3299548] TCF/LEF:CTNNB1 [nucleoplasm] - Bos taurus [Complex:R-SSC-3299548] TCF/LEF:CTNNB1 [nucleoplasm] - Sus scrofa [Complex:R-DRE-3299548] TCF/LEF:CTNNB1 [nucleoplasm] - Danio rerio [Complex:R-XTR-3299548] TCF/LEF:CTNNB1 [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-3299548] TCF/LEF:CTNNB1 [nucleoplasm] - Gallus gallus [Complex:R-DME-3299548] TCF/LEF:CTNNB1 [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-3299548] TCF/LEF:CTNNB1 [nucleoplasm] - Caenorhabditis elegans
isChimeric	false
literatureReference	[LiteratureReference:3299512] All Tcf HMG box transcription factors interact with Groucho-related co-repressors [LiteratureReference:3299516] Functional interaction of beta-catenin with the transcription factor LEF-1 [LiteratureReference:3299514] Crystal structure of a beta-catenin/Tcf complex [LiteratureReference:201944] Structure of a human Tcf4-beta-catenin complex [LiteratureReference:201927] Identification of Tcf4 residues involved in high-affinity beta-catenin binding [LiteratureReference:3299530] Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse
maxDepth	3
modified	[InstanceEdit:3451180] Rothfels, K, 2013-05-16
name	TCF/LEF:CTNNB1
producedByEvent	[Reaction:R-HSA-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-3299548

Referrals

(hasComponent)	[Complex:R-HSA-3322393] TCF/LEF:CTNNB1:PAF1-like complex [nucleoplasm] [Complex:R-HSA-3322396] TCF/LEF:CTNNB1:CBP/p300 [nucleoplasm] [Complex:R-HSA-3451129] TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm] [Complex:R-HSA-3322391] TCF/LEF:CTNNB1:SMARCA4:TERT [nucleoplasm] [Complex:R-HSA-5665607] TCF/LEF:CTNNB1:SOX4,SOX13,SOX17 [nucleoplasm] [Complex:R-HSA-8944361] 'canonical' WNT target genes:TCF/LEF:CTNNB1 [nucleoplasm]
(input)	[Reaction:R-HSA-3322424] Beta-catenin recruits CDC73 and LEO1 [Reaction:R-HSA-3322427] Beta-catenin recruits CBP/p300 [Reaction:R-HSA-3451153] Beta-catenin recruits TRRAP/KAT5 HAT components [Reaction:R-HSA-3322422] Beta-catenin recruits SMARCA4 [Reaction:R-HSA-5665608] TCF:Beta-catenin binds SOX proteins [Reaction:R-HSA-201712] Beta-catenin:TCF associates with BCL9 and PYGO [Reaction:R-HSA-8944362] TCF/LEF:CTNNB1 bind canonical WNT target promoters
(activeUnit)	[PositiveGeneExpressionRegulation:R-HSA-8944369] Positive gene expression regulation by ''canonical' WNT target genes:TCF/LEF:CTNNB1 [nucleoplasm]'
(output)	[Reaction:R-HSA-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF

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