Reactome | Stimuli-sensing channels

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Stimuli-sensing channels Show undefined attributes

authored	[InstanceEdit:2672349] Jassal, Bijay, 2012-11-27
created	[InstanceEdit:2672349] Jassal, Bijay, 2012-11-27
crossReference	[DatabaseIdentifier:12819499] BioModels Database:BIOMD0000000327
dbId	2672351
displayName	Stimuli-sensing channels
doi	10.3180/REACT_160189.1
edited	[InstanceEdit:2672349] Jassal, Bijay, 2012-11-27
eventOf	[Pathway:R-HSA-983712] Ion channel transport - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8863494] ASICs bind STOML3, (STOM) - Homo sapiens [Reaction:R-HSA-9650165] ASIC trimers bind H+ - Homo sapiens [Reaction:R-HSA-2671885] ASIC trimers:H+ transport extracellular Na+ to cytosol - Homo sapiens [Reaction:R-HSA-9649963] ASIC3 channel blockers bind ASIC3 trimer - Homo sapiens [Reaction:R-HSA-2672334] SCNN channels transport extracellular Na+ to cytosol - Homo sapiens [Reaction:R-HSA-2682349] RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels - Homo sapiens [Reaction:R-HSA-2684901] ANOs transport cytosolic Cl- to extracellular region - Homo sapiens [Reaction:R-HSA-9659568] ANO1 transports cytosolic Cl- to extracellular region - Homo sapiens [Reaction:R-HSA-9659611] ANO1 inhibitors bind ANO1 - Homo sapiens [Reaction:R-HSA-2685505] TPCN1/2 transport lysosomal Ca2+ to cytosol - Homo sapiens [Reaction:R-HSA-2730664] UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-2744228] CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region - Homo sapiens [Reaction:R-HSA-2731002] CLCN3 exchanges Cl- for H+ - Homo sapiens [Reaction:R-HSA-2730692] CLCN4/5/6 exchange Cl- for H+ - Homo sapiens [Reaction:R-HSA-2730959] CLCN7:OSTM1 exchanges Cl- for H+ - Homo sapiens [Reaction:R-HSA-5333671] CLCAs self cleave - Homo sapiens [Reaction:R-HSA-2744349] TTYH1 transports cytosolic Cl- to extracellular region - Homo sapiens [Reaction:R-HSA-2744242] TTYH2/3 transport cytosolic Cl- to extracellular region - Homo sapiens [Reaction:R-HSA-2744361] BESTs transport cytosolic Cl- to extracellular region - Homo sapiens [Reaction:R-HSA-2752067] BESTs transport cytosolic HCO3- to extracellular region - Homo sapiens [Reaction:R-HSA-2855020] RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol - Homo sapiens [Reaction:R-HSA-2872498] SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol - Homo sapiens [Reaction:R-HSA-2872497] SLC17A3-2 transports cytosolic urate to extracellular region - Homo sapiens [Reaction:R-HSA-2872444] SLC9B1/C2 exchange Na+ for H+ - Homo sapiens [Reaction:R-HSA-2889070] SLC9B2 exchanges Na+ for H+ - Homo sapiens [Reaction:R-HSA-2872463] SLC9C1 exchanges Na+ for H+ - Homo sapiens [Pathway:R-HSA-3295583] TRP channels - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-09-14
literatureReference	[LiteratureReference:2671946] Acidosis, acid-sensing ion channels, and neuronal cell death [LiteratureReference:2671967] ENaCs and ASICs as therapeutic targets [LiteratureReference:2672360] Acid-sensing ion channels (ASICs): pharmacology and implication in pain [LiteratureReference:2672339] TRP channels: sensors and transducers of gasotransmitter signals [Book:2672358] TRP Channels Xhu, Michael Chapter 3 Activation of TRP Channels in Mammalian Systems 9781439818602 [LiteratureReference:2672347] An introduction to TRP channels [LiteratureReference:2672346] The TRP superfamily of cation channels [LiteratureReference:2752042] Structure-function analysis of the bestrophin family of anion channels [LiteratureReference:2752039] The vitelliform macular dystrophy protein defines a new family of chloride channels [LiteratureReference:2900735] Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions [LiteratureReference:2900741] Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies [LiteratureReference:2744232] The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels [LiteratureReference:2855199] Control of muscle ryanodine receptor calcium release channels by proteins in the sarcoplasmic reticulum lumen
maxDepth	3
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Stimuli-sensing channels
orthologousEvent	[Pathway:R-SCE-2672351] Stimuli-sensing channels - Saccharomyces cerevisiae [Pathway:R-SPO-2672351] Stimuli-sensing channels - Schizosaccharomyces pombe [Pathway:R-DDI-2672351] Stimuli-sensing channels - Dictyostelium discoideum [Pathway:R-CEL-2672351] Stimuli-sensing channels - Caenorhabditis elegans [Pathway:R-DME-2672351] Stimuli-sensing channels - Drosophila melanogaster [Pathway:R-MMU-2672351] Stimuli-sensing channels - Mus musculus [Pathway:R-RNO-2672351] Stimuli-sensing channels - Rattus norvegicus [Pathway:R-CFA-2672351] Stimuli-sensing channels - Canis familiaris [Pathway:R-BTA-2672351] Stimuli-sensing channels - Bos taurus [Pathway:R-SSC-2672351] Stimuli-sensing channels - Sus scrofa [Pathway:R-DRE-2672351] Stimuli-sensing channels - Danio rerio [Pathway:R-XTR-2672351] Stimuli-sensing channels - Xenopus tropicalis [Pathway:R-GGA-2672351] Stimuli-sensing channels - Gallus gallus
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3002750] He, Lei, 2013-01-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2672351
summation	[Summation:2672361] Ion channels that mediate sensations such as pain, warmth, c...
updateTrackers	[UpdateTracker:9774810] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v81:[addHasEvent, updateContainedPathway] [UpdateTracker:9785789] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v51:[addHasEvent, updateIndirectRLE] [UpdateTracker:9775030] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v80:[updateContainedRLE] [UpdateTracker:9786196] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v50:[updateContainedRLE] [UpdateTracker:9776598] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v75:[updateContainedPathway] [UpdateTracker:9964702] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v94:[addHasEvent] [UpdateTracker:9787239] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v46:[addHasEvent] [UpdateTracker:9786587] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v49:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9847000] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v82:[updateContainedRLE] [UpdateTracker:9777157] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v72:[updateContainedRLE] [UpdateTracker:9776129] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v77:[updateContainedRLE] [UpdateTracker:9783278] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v57:[addHasEvent] [UpdateTracker:9780704] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v62:[updateContainedRLE] [UpdateTracker:9783977] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v55:[updateContainedRLE] [UpdateTracker:9785544] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v52:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9971806] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v95:[removeHasEvent] [UpdateTracker:9775788] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v78:[updateContainedRLE] [UpdateTracker:9777507] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v70:[addHasEvent] [UpdateTracker:9777457] Update Tracker - [Pathway:2672351] Stimuli-sensing channels - v71:[addHasEvent]

Referrals

(hasEvent)

[Pathway:R-HSA-983712] Ion channel transport

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