Reactome | ANOs transport cytosolic Cl- to extracellular region

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ANOs transport cytosolic Cl- to extracellular region Show undefined attributes

authored	[InstanceEdit:2684910] Jassal, Bijay, 2012-12-03
catalystActivity	[CatalystActivity:2684928] chloride channel activity of ANOs [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2684910] Jassal, Bijay, 2012-12-03
crossReference	[DatabaseIdentifier:12667891] RHEA:29823
dbId	2684901
displayName	ANOs transport cytosolic Cl- to extracellular region
edited	[InstanceEdit:2684910] Jassal, Bijay, 2012-12-03
eventOf	[Pathway:R-HSA-2672351] Stimuli-sensing channels - Homo sapiens
input	[SimpleEntity:R-ALL-352022] Cl- [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2684946] The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels [LiteratureReference:2684916] TMEM16A confers receptor-activated calcium-dependent chloride conductance [LiteratureReference:2684903] Anoctamins are a family of Ca2+ activated Cl- channels
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ANOs transport cytosolic Cl- to extracellular region Cytosolic Cl- is transported to extracellular region by ANOs
orthologousEvent	[Reaction:R-SCE-2684901] ANOs transport cytosolic Cl- to extracellular region - Saccharomyces cerevisiae [Reaction:R-SPO-2684901] ANOs transport cytosolic Cl- to extracellular region - Schizosaccharomyces pombe [Reaction:R-DDI-2684901] ANOs transport cytosolic Cl- to extracellular region - Dictyostelium discoideum [Reaction:R-CEL-2684901] ANOs transport cytosolic Cl- to extracellular region - Caenorhabditis elegans [Reaction:R-DME-2684901] ANOs transport cytosolic Cl- to extracellular region - Drosophila melanogaster [Reaction:R-GGA-2684901] ANOs transport cytosolic Cl- to extracellular region - Gallus gallus [Reaction:R-XTR-2684901] ANOs transport cytosolic Cl- to extracellular region - Xenopus tropicalis [Reaction:R-DRE-2684901] ANOs transport cytosolic Cl- to extracellular region - Danio rerio [Reaction:R-SSC-2684901] ANOs transport cytosolic Cl- to extracellular region - Sus scrofa [Reaction:R-BTA-2684901] ANOs transport cytosolic Cl- to extracellular region - Bos taurus [Reaction:R-CFA-2684901] ANOs transport cytosolic Cl- to extracellular region - Canis familiaris [Reaction:R-RNO-2684901] ANOs transport cytosolic Cl- to extracellular region - Rattus norvegicus [Reaction:R-MMU-2684901] ANOs transport cytosolic Cl- to extracellular region - Mus musculus
output	[SimpleEntity:R-ALL-188972] Cl- [extracellular region]
regulatedBy	[PositiveRegulation:R-HSA-2684957] Positive regulation by 'Ca2+ [cytosol]' [PositiveRegulation:R-HSA-5336171] Positive regulation by 'N-terminus CLCAs [plasma membrane]'
regulationReference	[RegulationReference:9642572] Positive regulation by 'N-terminus CLCAs [plasma membrane]' Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3002750] He, Lei, 2013-01-28
revised	[InstanceEdit:5674206] Jassal, Bijay, 2015-02-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2684901
summation	[Summation:2684912] Calcium-activated chloride channels (CaCCs) are ubiquitously...
updateTrackers	[UpdateTracker:9776038] Update Tracker - [Reaction:2684901] ANOs transport cytosolic Cl- to extracellular region - v78:[modifyText] [UpdateTracker:9786366] Update Tracker - [Reaction:2684901] ANOs transport cytosolic Cl- to extracellular region - v49:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9776038] Update Tracker - [Reaction:2684901] ANOs transport cytosolic Cl- to extracellular region - v78:[modifyText] [UpdateTracker:9786366] Update Tracker - [Reaction:2684901] ANOs transport cytosolic Cl- to extracellular region - v49:[addRegulator]
(hasEvent)	[Pathway:R-HSA-2672351] Stimuli-sensing channels

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