Reactome | Stimuli-sensing channels

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Stimuli-sensing channels Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100945
displayName	Stimuli-sensing channels
eventOf	[Pathway:R-MMU-983712] Ion channel transport - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-8863494] ASICs bind STOML3, (STOM) - Mus musculus [Reaction:R-MMU-9650165] ASIC trimers bind H+ - Mus musculus [Reaction:R-MMU-2671885] ASIC trimers:H+ transport extracellular Na+ to cytosol - Mus musculus [Reaction:R-MMU-9649963] ASIC3 channel blockers bind ASIC3 trimer - Mus musculus [Reaction:R-MMU-2672334] SCNN channels transport extracellular Na+ to cytosol - Mus musculus [Reaction:R-MMU-2682349] RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels - Mus musculus [Reaction:R-MMU-2684901] ANOs transport cytosolic Cl- to extracellular region - Mus musculus [Reaction:R-MMU-9659568] ANO1 transports cytosolic Cl- to extracellular region - Mus musculus [Reaction:R-MMU-9659611] ANO1 inhibitors bind ANO1 - Mus musculus [Reaction:R-MMU-2685505] TPCN1/2 transport lysosomal Ca2+ to cytosol - Mus musculus [Reaction:R-MMU-2730664] UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol - Mus musculus [Reaction:R-MMU-2744228] CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region - Mus musculus [Reaction:R-MMU-2730692] CLCN4/5/6 exchange Cl- for H+ - Mus musculus [Reaction:R-MMU-2730959] CLCN7:OSTM1 exchanges Cl- for H+ - Mus musculus [Reaction:R-MMU-5333671] CLCAs self cleave - Mus musculus [Reaction:R-MMU-2744349] TTYH1 transports cytosolic Cl- to extracellular region - Mus musculus [Reaction:R-MMU-2744242] TTYH2/3 transport cytosolic Cl- to extracellular region - Mus musculus [Reaction:R-MMU-2744361] BESTs transport cytosolic Cl- to extracellular region - Mus musculus [Reaction:R-MMU-2752067] BESTs transport cytosolic HCO3- to extracellular region - Mus musculus [Reaction:R-MMU-2855020] RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol - Mus musculus [Reaction:R-MMU-2872498] SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol - Mus musculus [Reaction:R-MMU-2872497] SLC17A3-2 transports cytosolic urate to extracellular region - Mus musculus [Reaction:R-MMU-2872444] SLC9B1/C2 exchange Na+ for H+ - Mus musculus [Reaction:R-MMU-2889070] SLC9B2 exchanges Na+ for H+ - Mus musculus [Pathway:R-MMU-3295583] TRP channels - Mus musculus
inferredFrom	[Pathway:R-HSA-2672351] Stimuli-sensing channels - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Stimuli-sensing channels
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-2672351
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-983712] Ion channel transport
(inferredTo)	[Pathway:R-HSA-2672351] Stimuli-sensing channels

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