Reactome | CLCN4/5/6 exchange Cl- for H+

Schema > Reaction > Entries

CLCN4/5/6 exchange Cl- for H+ Show undefined attributes

authored	[InstanceEdit:2730691] Jassal, Bijay, 2012-12-04
catalystActivity	[CatalystActivity:2730696] antiporter activity of CLCN4/5/6 [endosome membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:171907] endosome lumen [Compartment:74700] endosome membrane
created	[InstanceEdit:2730691] Jassal, Bijay, 2012-12-04
dbId	2730692
displayName	CLCN4/5/6 exchange Cl- for H+
edited	[InstanceEdit:2730691] Jassal, Bijay, 2012-12-04
eventOf	[Pathway:R-HSA-2672351] Stimuli-sensing channels - Homo sapiens
input	[SimpleEntity:R-ALL-2731008] Cl- [endosome lumen] [SimpleEntity:R-ALL-70106] H+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2730698] The late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression [LiteratureReference:2730681] Determinants of anion-proton coupling in mammalian endosomal CLC proteins [LiteratureReference:2730699] Identification of an acid-activated Cl(-) channel from human skeletal muscles
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	CLCN4/5/6 exchange Cl- for H+
orthologousEvent	[Reaction:R-SCE-2730692] CLCN4/5/6 exchange Cl- for H+ - Saccharomyces cerevisiae [Reaction:R-SPO-2730692] CLCN4/5/6 exchange Cl- for H+ - Schizosaccharomyces pombe [Reaction:R-DDI-2730692] CLCN4/5/6 exchange Cl- for H+ - Dictyostelium discoideum [Reaction:R-CEL-2730692] CLCN4/5/6 exchange Cl- for H+ - Caenorhabditis elegans [Reaction:R-DME-2730692] CLCN4/5/6 exchange Cl- for H+ - Drosophila melanogaster [Reaction:R-GGA-2730692] CLCN4/5/6 exchange Cl- for H+ - Gallus gallus [Reaction:R-XTR-2730692] CLCN4/5/6 exchange Cl- for H+ - Xenopus tropicalis [Reaction:R-DRE-2730692] CLCN4/5/6 exchange Cl- for H+ - Danio rerio [Reaction:R-SSC-2730692] CLCN4/5/6 exchange Cl- for H+ - Sus scrofa [Reaction:R-BTA-2730692] CLCN4/5/6 exchange Cl- for H+ - Bos taurus [Reaction:R-CFA-2730692] CLCN4/5/6 exchange Cl- for H+ - Canis familiaris [Reaction:R-RNO-2730692] CLCN4/5/6 exchange Cl- for H+ - Rattus norvegicus [Reaction:R-MMU-2730692] CLCN4/5/6 exchange Cl- for H+ - Mus musculus
output	[SimpleEntity:R-ALL-352022] Cl- [cytosol] [SimpleEntity:R-ALL-74722] H+ [endosome lumen]
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3002750] He, Lei, 2013-01-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2730692
summation	[Summation:2730685] The H+/Cl- exchange transporters CLCN4 (Kawasaki et al. 1999...

Referrals

(hasEvent)

[Pathway:R-HSA-2672351] Stimuli-sensing channels